ARPC1B and PMPCB

		ARPC1B	PMPCB
Description		actin related protein 2/3 complex subunit 1B	peptidase, mitochondrial processing subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome	Mitochondrion Mitochondrial Matrix Mitochondrial Processing Peptidase Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-containing Complex Binding Actin Filament Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Response To Estrogen	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Mitochondrial protein import Processing of SMDT1
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Alcohol consumption ( 31358974) Facial emotion recognition (sad faces) ( 28608620) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 23093944)	Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		11 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA CEBPA PAK1 SRPK2 WAS	5 interacting genes: FXN MARK3 NPSR1 PMPCA PTGER4
Entrez ID		10095	9512
HPRD ID		10366	07539
Ensembl ID		ENSG00000130429	ENSG00000105819
Uniprot IDs		A4D275 O15143	A0A9L9PXG6 A0A9L9PXH0 A0A9L9PXI7 B3KM34 G3V0E4 O75439 Q96CP5
PDB IDs		6UHC 6YW6 8P94
Enriched GO Terms of Interacting Partners?		Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Site Of Double-strand Break Actin Cytoskeleton Actin Filament Supramolecular Fiber Organization Actin Filament Organization Actin Filament Polymerization Cytoskeleton Regulation Of Lamellipodium Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Filament-based Process Focal Adhesion Lamellipodium Actin Polymerization Or Depolymerization Cell Projection Actin Filament Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Presynapse Positive Regulation Of DNA Recombination Protein Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Cytokine Regulation Of Actin Filament Organization Response To Peptide Positive Regulation Of Double-strand Break Repair Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Projection Organization Cellular Component Assembly Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Cytosol Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of DNA Recombination Positive Regulation Of DNA Repair
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