KCNK7 and CFHR5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNK7	CFHR5
Description		potassium two pore domain channel subfamily K member 7	complement factor H related 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Extracellular Region Extracellular Space Protein-containing Complex
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity	Complement Component C3b Binding Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Complement Activation Complement Activation, Alternative Pathway Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells
Pathways		Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	Regulation of Complement cascade
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Rosacea symptom severity ( 29771307)	Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (MTAG) ( 32277175) Asthma ( 29273806) Lupus nephritis in systemic lupus erythematosus ( 24925725) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)
Interacting Genes		1 interacting genes: CFHR5	21 interacting genes: ARL13B C3 CFTR CISD2 CREB3 CREB3L1 EBAG9 ERGIC3 FFAR2 GPX8 KCNK7 LMNA PANX1 SLC10A1 SLC18A2 SLC4A1 SLC71A2 STOM TMEM14B TMEM237 TMPRSS2
Entrez ID		10089	81494
HPRD ID		06804	06508
Ensembl ID		ENSG00000173338	ENSG00000134389
Uniprot IDs		Q3SYI1 Q9Y2U2	Q9BXR6
PDB IDs
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Cytolysis By Host Of Symbiont Cells Complement Component C3b Binding Biological Process Involved In Interaction With Symbiont Negative Regulation Of Protein Binding Regulation Of Protein Binding Complement Activation Killing By Host Of Symbiont Cells Killing Of Cells Of Another Organism Cell Killing Humoral Immune Response	Membrane Bicarbonate Transmembrane Transporter Activity
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