SETMAR

Description		SET and mariner transposase domain methyltransferase
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Chromosome Nucleolus Site Of Double-strand Break
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Hydrolase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Protein Homodimerization Activity DNA Topoisomerase Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity
	Biological Process	DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Catabolic Process Chromatin Organization Chromatin Remodeling DNA Damage Response Cell Population Proliferation DNA Integration Replication Fork Processing Methylation Mitotic DNA Integrity Checkpoint Signaling Nucleic Acid Metabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization
Pathways
Drugs
Diseases
GWAS		Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spondylosis ( 33332786)
Novel Interacting Genes		1 novel interacting genes: XRN2
Interacting Genes		3 interacting genes: H3-5 PRPF19 VPS26C
Entrez ID		6419
HPRD ID		10225
Ensembl ID		ENSG00000170364
Uniprot IDs		B4DND2 Q53H47 Q96H41
PDB IDs		3BO5 3F2K 3K9J 3K9K 7S03
Enriched GO Terms of Interacting Partners?
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