SETMAR

Gene Name		SET domain and mariner transposase fusion gene
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Site Of Double-strand Break
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Transposase Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Protein Homodimerization Activity Structure-specific DNA Binding DNA Topoisomerase Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	DNA Double-strand Break Processing DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Via Nonhomologous End Joining Transposition, DNA-mediated Cell Proliferation Histone H3-K36 Methylation DNA Integration Replication Fork Processing Mitotic DNA Integrity Checkpoint Histone H3-K4 Methylation Negative Regulation Of Cell Cycle Arrest Nucleic Acid Phosphodiester Bond Hydrolysis Histone H3-K36 Dimethylation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: H3F3C
Entrez ID		6419
HPRD ID		10225
Ensembl ID		ENSG00000170364
Uniprot IDs		B4DY74 C9JHK2 E7EN68 Q53H47
PDB IDs		3BO5 3F2K 3K9J 3K9K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Growth Positive Regulation Of Growth Regulation Of Cell Growth
Tagcloud ?		arrests associates break chk1 concerted differentiates dsb dsbs effectors effort fails fork forks ionizing lend lys36 methylates metnase phosphorylating repair replication repressing restart s495 s495a ser495 ser495ala stalled transposase