RPS6KA2 and DYNLT2

		RPS6KA2	DYNLT2
Description		ribosomal protein S6 kinase A2	dynein light chain Tctex-type 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Synapse Meiotic Spindle	Cytoplasm Cytoskeleton Cytoplasmic Dynein Complex Microtubule Membrane Dynein Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus	Microtubule-based Movement
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Intraflagellar transport
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756 34002096) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Café-au-lait macule number in neurofibromatosis type1 ( 32869517) Dental caries ( 23259602) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 23128233 27569725) Macrovascular complications in type 2 diabetes ( 33430853) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		12 interacting genes: BAD CREB1 FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1 TP53
Entrez ID		6196	6991
HPRD ID		03403	01747
Ensembl ID		ENSG00000071242	ENSG00000184786
Uniprot IDs		B7Z3B5 F2Z2J1 Q15349 X5D337	Q8IZS6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Face Development Schwann Cell Development Animal Organ Formation ERBB2 Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Lung Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Regulation Of Stress-activated MAPK Cascade Cell Differentiation Gland Development Anatomical Structure Morphogenesis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cellular Component Organization Response To Lipid Cell Surface Receptor Signaling Pathway Response To Nicotine Transcription Factor AP-1 Complex Regulation Of Cell Development Thymus Development Intracellular Signaling Cassette Cardiac Neural Crest Cell Development Involved In Heart Development Response To Epidermal Growth Factor ERK1 And ERK2 Cascade Positive Regulation Of MiRNA Transcription Outer Ear Morphogenesis Identical Protein Binding Cellular Response To Starvation Positive Regulation Of MiRNA Metabolic Process Glial Cell Development Response To Mechanical Stimulus	Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Oocyte Maturation Meiotic Spindle Cardiac Muscle Cell Apoptotic Process Protein Serine/threonine/tyrosine Kinase Activity Heart Contraction Negative Regulation Of Meiotic Nuclear Division Striated Muscle Cell Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Ribosomal Protein S6 Kinase Activity Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Negative Regulation Of Meiotic Cell Cycle Regulation Of Blood Volume By Renin-angiotensin Muscle Cell Apoptotic Process Heart Process Regulation Of Meiotic Nuclear Division Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Processing Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process TORC1 Signaling Regulation Of Protein Maturation Cellular Response To Carbohydrate Stimulus TOR Signaling Regulation Of Nuclear Division Cell Maturation Response To Carbohydrate Regulation Of Blood Pressure Regulation Of Reproductive Process Developmental Maturation Magnesium Ion Binding Spindle Heart Development Negative Regulation Of Cell Cycle Process
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