KMT2E and NFE4

		KMT2E	NFE4
Description		lysine methyltransferase 2E (inactive)	nuclear factor, erythroid 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Membrane Nuclear Body Nuclear Speck Protein-containing Complex Set3 Complex Rpd3L-Expanded Complex	Nucleus Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3 Methyltransferase Activity	Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Protein Homodimerization Activity DNA-binding Transcription Factor Binding
	Biological Process	Neutrophil Mediated Immunity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Erythrocyte Differentiation Epigenetic Regulation Of Gene Expression Neutrophil Activation Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		6 interacting genes: ASH2L ATP13A1 CDCA8 CDK1 CRK LAMTOR5	3 interacting genes: HDAC1 KAT2B TFCP2
Entrez ID		55904	58160
HPRD ID		10528	19326
Ensembl ID		ENSG00000005483	ENSG00000230257
Uniprot IDs		Q8IZD2
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Spindle Microtubules To Kinetochore Organelle Assembly Spindle Midzone Positive Regulation Of Chromosome Segregation Protein-containing Complex Pronuclear Fusion Spindle Cytoskeleton Organization DNA N6-methyladenine Demethylase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Mitotic DNA-templated DNA Replication Cellular Component Assembly Cyclin B1-CDK1 Complex Cilium Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Helper T Cell Diapedesis Positive Regulation Of Intracellular Signal Transduction Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Small GTPase Mediated Signal Transduction Linoleic Acid Epoxygenase Activity Epigenetic Regulation Of Gene Expression Positive Regulation Of ARF Protein Signal Transduction Cleavage Furrow Ingression Intracellular Protein Localization Response To Activity Regulation Of Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome Organization Cyclin-dependent Protein Kinase Activity Cerebellar Neuron Development Response To Flavonoid P-type Transmembrane Transporter Activity Spindle Assembly Regulation Of Schwann Cell Differentiation Response To Hydrogen Peroxide Microtubule-based Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Protein Localization To Nucleus Response To Toxic Substance	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition RNA 5'-gamma-phosphate Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Krueppel-associated Box Domain Binding Histone Deacetylase Binding Chromatin Remodeling Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity Set3 Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Rpd3L-Expanded Complex Regulation Of Cell Cycle Process Protein Lysine Delactylase Activity Fungiform Papilla Formation N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Decrotonylase Activity Histone Decrotonylase Activity DNA-binding Transcription Factor Binding Chromatin Organization Negative Regulation Of Ribosome Biogenesis Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Hair Follicle Placode Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II
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