CEP192

Description		centrosomal protein 192
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GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Procentriole Procentriole Replication Complex
	Molecular Function	Protein Binding Phosphatase Binding
	Biological Process	Centrosome Cycle Centriole Replication Response To Bacterium Centrosome Duplication Protein Localization To Centrosome Centrosome-templated Microtubule Nucleation Mitotic Spindle Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) General cognitive ability ( 29844566)
Novel Interacting Genes		2 novel interacting genes: CTAGE1 SPIRE1
Interacting Genes		5 interacting genes: CIP2A LINC00839 PPP1CA SHBG UBC
Entrez ID		55125
HPRD ID		10855
Ensembl ID		ENSG00000101639
Uniprot IDs		Q8TEP8
PDB IDs		4N7Z 6FVI 6W3J 7PTB 8GUW 8PR7
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Androgen Binding Mitochondrial Outer Membrane Meiotic Cytokinesis Formin-nucleated Actin Cable Assembly Parallel Actin Filament Bundle Assembly Establishment Of Meiotic Spindle Localization Polar Body Extrusion After Meiotic Divisions Cleavage Furrow Formation Actin Filament Network Formation Broken Chromosome Clustering
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