PPP1R12B

Description		protein phosphatase 1 regulatory subunit 12B
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Cytoskeleton Z Disc A Band
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Regulation Of Muscle Contraction Signal Transduction Neuron Projection Morphogenesis
Pathways		RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Chronic obstructive pulmonary disease ( 32824824) Coronary heart disease ( 24778558) Obesity-related traits ( 23251661) Sex ratio ( 26763874)
Interacting Genes		3 interacting genes: IL16 PPP1CB PRKG1
Entrez ID		4660
HPRD ID		04794
Ensembl ID		ENSG00000077157
Uniprot IDs		A0A994J7P4 E1CKY7 O60237
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Myosin-light-chain-phosphatase Activity CGMP-dependent Protein Kinase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Neutrophil Activation Positive Regulation Of Interleukin-1 Alpha Production Myosin Phosphatase Activity PTW/PP1 Phosphatase Complex Mitogen-activated Protein Kinase P38 Binding Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Negative Regulation Of Glutamate Secretion Relaxation Of Vascular Associated Smooth Muscle CD4 Receptor Binding Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neutrophil Activation Focal Adhesion Induction Of Positive Chemotaxis Negative Regulation Of Amino Acid Transport CGMP Binding Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Positive Regulation Of Circadian Rhythm Relaxation Of Muscle Collateral Sprouting Negative Regulation Of Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Bone Growth Regulation Of Glutamate Secretion Negative Regulation Of Platelet Activation Regulation Of Ketone Biosynthetic Process Regulation Of Cell Activation Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Positive Chemotaxis Photoperiodism Entrainment Of Circadian Clock CGMP-mediated Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Platelet Aggregation Flemming Body Regulation Of Cell Adhesion Intracellular Signaling Cassette Positive Regulation Of Interleukin-12 Production Dendrite Development Cell Migration Calcium Channel Regulator Activity Regulation Of Vascular Permeability Organ Growth
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