IFT172 and RAB10

		IFT172	RAB10
Description		intraflagellar transport 172	RAB10, member RAS oncogene family
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GO Annotations	Cellular Component	Cilium Axoneme Intraciliary Transport Particle Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip Sperm Cytoplasmic Droplet Extracellular Vesicle	Golgi Membrane Exocyst Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Cell Projection Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network Secretory Vesicle
	Molecular Function		Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Neural Tube Formation Neural Tube Closure Heart Looping Notch Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Heart Development Epidermis Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Negative Regulation Of Keratinocyte Proliferation Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Development Cytoplasmic Microtubule Organization Intraciliary Anterograde Transport Intraciliary Transport Keratinocyte Proliferation Cilium Organization Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Limb Development Cilium Assembly Bone Development Hindgut Development Left/right Axis Specification Non-motile Cilium Assembly	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Protein Transport Vesicle-mediated Transport Endosomal Transport Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport	Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Calcium levels ( 20705733) Chronic kidney disease ( 20383146) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Total cholesterol levels ( 30718733)	Apolipoprotein B levels ( 32203549) Glycated hemoglobin levels ( 34059833) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: LCOR LHX3 LHX4	10 interacting genes: APP CEBPA ENOPH1 EVI5L MICAL1 MTNR1A PPBP RABIF RIMS1 SEPTIN9
Entrez ID		26160	10890
HPRD ID		09576	06692
Ensembl ID		ENSG00000138002	ENSG00000084733
Uniprot IDs		A0A6Q8PGJ2 Q9UG01	P61026
PDB IDs		9H2D	5LPN 5SZJ
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Cell Differentiation In Spinal Cord Placenta Development Ventral Spinal Cord Interneuron Specification Prolactin Secreting Cell Differentiation Somatotropin Secreting Cell Differentiation Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Thyroid-stimulating Hormone-secreting Cell Differentiation Protein Localization To Plasma Membrane Insulin-responsive Compartment Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Protein Localization To Cell Periphery Secretory Vesicle
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