SIRT5 and RNF182

		SIRT5	RNF182
Description		sirtuin 5	ring finger protein 182
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol	Cytoplasm Membrane
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent NAD-dependent Protein Lysine Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Ischemia Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Nutrient Levels Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Protein Ubiquitination
Pathways		Transcriptional activation of mitochondrial biogenesis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Perceived intensity of sweet substances ( 31005972)	Lymphoma ( 23349640) Mean corpuscular hemoglobin concentration ( 27863252) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: APP TP53 TRIM21 USP7	6 interacting genes: ANTXR1 UBC UBE2D1 UBE2K UBE2L3 UBE2N
Entrez ID		23408	221687
HPRD ID		06838	15264
Ensembl ID		ENSG00000124523	ENSG00000180537
Uniprot IDs		A0A7P0T9N1 A0A7P0Z4N6 Q9NXA8	Q8N6D2
PDB IDs		2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJK 6LJM 6LJN 7X3P 8GBL 8GBN
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Molecular Function Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Triterpenoid Biosynthetic Process Lanosterol Synthase Activity Regulation Of Autophagy P53 Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleotide-excision Repair Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Intramolecular Transferase Activity Autophagosome Organization Negative Regulation Of Protein Metabolic Process Autophagosome Assembly	Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification Process Post-translational Protein Modification Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Polyubiquitination Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Transferase Activity Catabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Peptidyl-lysine Demalonylation Protein Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein-malonyllysine Demalonylase Activity TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Response To Nutrient Levels Protein K48-linked Ubiquitination Protein-glutaryllysine Deglutarylase Activity Protein-succinyllysine Desuccinylase Activity Protein Deglutarylation Ubiquitin Ligase Complex ATP Binding UBC13-MMS2 Complex Regulation Of TOR Signaling Ubiquitin Conjugating Enzyme Complex Regulation Of Protein Metabolic Process Histone Deacetylase Activity, NAD-dependent Macromolecule Metabolic Process Nucleotide Binding
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