RHOBTB1 and CUL5

Number of citations of the paper that reports this interaction (PubMedID 18835386)
43

Data Source:
BioGRID (two hybrid)

		RHOBTB1	CUL5
Description		Rho related BTB domain containing 1	cullin 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Endosome Membrane Cytoplasmic Vesicle Cell Projection	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Cell Migration Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Reelin-mediated Signaling Pathway ERBB2 Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Defense Response To Virus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Symbiont-mediated Suppression Of Host Innate Immune Response Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Calcium Ion Transmembrane Transport Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Neuron Migration
Pathways		RHOBTB1 GTPase cycle	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		Diastolic blood pressure ( 19430483) Femur bone mineral density x serum urate levels interaction ( 34046847) Food allergy ( 25710614) Lean body mass ( 28552196) Metabolite levels ( 23823483) Milk allergy ( 25710614) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Refractive error ( 32231278)
Interacting Genes		2 interacting genes: ARID5B CUL5	42 interacting genes: ANAPC11 APOBEC3C APOBEC3G ASB11 CCNB1IP1 CCNDBP1 CKB COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBA3 UBC UBE2L3 VHL
Entrez ID		9886	8065
HPRD ID		06299	03444
Ensembl ID		ENSG00000072422	ENSG00000166266
Uniprot IDs		O94844	Q93034
PDB IDs			3DPL 3DQV 4JGH 4N9F 6V9I 7ONI 8EI2 8FVI 8FVJ
Enriched GO Terms of Interacting Partners?		Symbiont-mediated Suppression Of Host Innate Immune Response Negative Regulation Of Focal Adhesion Disassembly Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Scaffold Activity Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Muscle Organ Morphogenesis Fat Pad Development Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of CGAS/STING Signaling Pathway Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Fibroblast Migration Cell Migration ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Adrenal Gland Development Female Gonad Development CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cell Motility Face Morphogenesis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K11-linked Ubiquitination Site Of DNA Damage Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Migration Adipose Tissue Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell-matrix Adhesion SCF Ubiquitin Ligase Complex Negative Regulation Of Cell-substrate Adhesion Endoplasmic Reticulum Unfolded Protein Response Regulation Of Focal Adhesion Assembly Connective Tissue Development Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Post-embryonic Development Roof Of Mouth Development Calcium Channel Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway	Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Deneddylation Regulation Of Protein Neddylation Protein Modification Process Regulation Of Post-translational Protein Modification COP9 Signalosome Regulation Of Protein Modification Process Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteolysis Nucleoplasm Cytosol NEDD8 Transferase Activity Cullin Family Protein Binding Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Nucleus I-SMAD Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Protein Ubiquitination Ubiquitin Protein Ligase Binding Cul2-RING Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC1 Signaling Elongin Complex Ubiquitin-protein Transferase Activity NEDD8 Ligase Activity COP9 Signalosome Assembly Cytoplasm Endosome Membrane Negative Regulation Of TOR Signaling Phosphocreatine Biosynthetic Process DeNEDDylase Activity Regulation Of Metabolic Process
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