CUL5 and COMMD1

Number of citations of the paper that reports this interaction (PubMedID 21778237)
40

Data Source:
BioGRID (pull down)

		CUL5	COMMD1
Description		cullin 5	copper metabolism domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Cul2-RING Ubiquitin Ligase Complex Recycling Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Ubiquitin Ligase Complex Scaffold Activity	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Cell Migration Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Reelin-mediated Signaling Pathway ERBB2 Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Defense Response To Virus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Symbiont-mediated Suppression Of Host Innate Immune Response Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Calcium Ion Transmembrane Transport Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Neuron Migration	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle Clearance Protein Localization To Cell Surface Cholesterol Homeostasis Plasma Membrane To Endosome Transport Copper Ion Homeostasis Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses	Neddylation
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)
Interacting Genes		42 interacting genes: ANAPC11 APOBEC3C APOBEC3G ASB11 CCNB1IP1 CCNDBP1 CKB COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBA3 UBC UBE2L3 VHL	38 interacting genes: BAHCC1 BARD1 BRCA1 C2orf74 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC GRSF1 HMGB2 KAT2A LIG4 NFKBIA PRKN RELA RIPPLY3 SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 TMEM132D UPRT VHL WDPCP XIAP
Entrez ID		8065	150684
HPRD ID		03444	06253
Ensembl ID		ENSG00000166266	ENSG00000173163
Uniprot IDs		Q93034	Q8N668
PDB IDs		3DPL 3DQV 4JGH 4N9F 6V9I 7ONI 8EI2 8FVI 8FVJ	2H2M 8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Deneddylation Regulation Of Protein Neddylation Protein Modification Process Regulation Of Post-translational Protein Modification COP9 Signalosome Regulation Of Protein Modification Process Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteolysis Nucleoplasm Cytosol NEDD8 Transferase Activity Cullin Family Protein Binding Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Nucleus I-SMAD Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Protein Ubiquitination Ubiquitin Protein Ligase Binding Cul2-RING Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC1 Signaling Elongin Complex Ubiquitin-protein Transferase Activity NEDD8 Ligase Activity COP9 Signalosome Assembly Cytoplasm Endosome Membrane Negative Regulation Of TOR Signaling Phosphocreatine Biosynthetic Process DeNEDDylase Activity Regulation Of Metabolic Process	Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Ubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Post-translational Protein Modification NF-kappaB Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cellular Response To Stress Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Intrinsic Apoptotic Signaling Pathway Nucleoplasm Positive Regulation Of Protein Linear Polyubiquitination Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Nucleus Regulation Of Multicellular Organismal Development Apoptotic Signaling Pathway Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway SCF Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of DNA Damage Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Protein K6-linked Ubiquitination BRCA1-B Complex Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Catabolic Process Proteolysis Cellular Response To Radiation Cytoplasm Regulation Of Cytokine Production Negative Regulation Of Cell Communication
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