CUL5 and RHOBTB2

Number of citations of the paper that reports this interaction (PubMedID 18835386)
43

Data Source:
BioGRID (two hybrid)

		CUL5	RHOBTB2
Description		cullin 5	Rho related BTB domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Cytoskeleton Plasma Membrane Endosome Membrane Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Ubiquitin Ligase Complex Scaffold Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Cell Migration Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Reelin-mediated Signaling Pathway ERBB2 Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Defense Response To Virus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Symbiont-mediated Suppression Of Host Innate Immune Response Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Calcium Ion Transmembrane Transport Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Neuron Migration	Ubiquitin-dependent Protein Catabolic Process Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Protein Ubiquitination Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses	RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Alzheimer's disease progression score ( 29860282) Aspartate aminotransferase levels ( 33547301) Basal cell carcinoma ( 33549134) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)
Interacting Genes		42 interacting genes: ANAPC11 APOBEC3C APOBEC3G ASB11 CCNB1IP1 CCNDBP1 CKB COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBA3 UBC UBE2L3 VHL	12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11
Entrez ID		8065	23221
HPRD ID		03444	06300
Ensembl ID		ENSG00000166266	ENSG00000008853
Uniprot IDs		Q93034	Q9BYZ6
PDB IDs		3DPL 3DQV 4JGH 4N9F 6V9I 7ONI 8EI2 8FVI 8FVJ
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Deneddylation Regulation Of Protein Neddylation Protein Modification Process Regulation Of Post-translational Protein Modification COP9 Signalosome Regulation Of Protein Modification Process Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteolysis Nucleoplasm Cytosol NEDD8 Transferase Activity Cullin Family Protein Binding Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Nucleus I-SMAD Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Protein Ubiquitination Ubiquitin Protein Ligase Binding Cul2-RING Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC1 Signaling Elongin Complex Ubiquitin-protein Transferase Activity NEDD8 Ligase Activity COP9 Signalosome Assembly Cytoplasm Endosome Membrane Negative Regulation Of TOR Signaling Phosphocreatine Biosynthetic Process DeNEDDylase Activity Regulation Of Metabolic Process	Ubiquitin Protein Ligase Binding Cellular Response To Stress Response To Stress ATP Binding Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Protein Localization Protein Metabolic Process Protein Stabilization Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To Unfolded Protein Protein Dephosphorylation Cellular Response To Growth Factor Stimulus Protein Modification Process Signal Transduction By P53 Class Mediator Regulation Of Protein Modification Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Protein Autophosphorylation Negative Regulation Of Cell Population Proliferation Dephosphorylation Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase Regulation Of Protein Stability DNA Polymerase Binding Phosphorylation ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Axonal Growth Cone RNA-templated DNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Phosphate-containing Compound Metabolic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Cell Cycle Phase Transition Negative Regulation Of Apoptotic Process Myelin Sheath Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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