CD40LG and IGKC

Number of citations of the paper that reports this interaction (PubMedID 11525169)
0

Data Source:
HPRD (in vitro)

		CD40LG	IGKC
Description		CD40 ligand	immunoglobulin kappa constant
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Extracellular Exosome IgG Immunoglobulin Complex IgD Immunoglobulin Complex IgE Immunoglobulin Complex IgA Immunoglobulin Complex IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding Protein Serine/threonine Kinase Activator Activity	Antigen Binding
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Immune System Process Inflammatory Response Immune Response Cell Communication Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression CD40 Signaling Pathway Signaling Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Isotype Switching Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Adaptive Immune Response Immune System Process Immune Response Immunoglobulin Mediated Immune Response B Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Ruplizumab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		CD40 ligand levels ( 25147954) Lymphocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: CD40 CD5L IGHG1 IGKC PHB1 RNF128 TP53	7 interacting genes: CD40LG CFTR IGHG1 MLH1 PLGLB2 REG3A SMARCD1
Entrez ID		959	3514
HPRD ID		02311	00921
Ensembl ID		ENSG00000102245	ENSG00000211592
Uniprot IDs		P29965
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB 6W9G 7SGM
Enriched GO Terms of Interacting Partners?		Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Binding B Cell Mediated Immunity Adaptive Immune Response IgG Immunoglobulin Complex Regulation Of Immune Response Immune System Process Blood Microparticle Immune Response-regulating Signaling Pathway Immune Effector Process Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Immunoglobulin Complex Regulation Of Complement Activation Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Humoral Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immunoglobulin Production Immune Response-activating Signaling Pathway Positive Regulation Of Complement-dependent Cytotoxicity Enzyme Binding Positive Regulation Of Immune System Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Complement Component C3a Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Immunoglobulin Production Activation Of Immune Response Lymphocyte Activation Defense Response Inflammatory Response Positive Regulation Of Programmed Cell Death Immune Response Leukocyte Activation Lymphocyte Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Mononuclear Cell Proliferation Response To Cobalamin Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Mitochondrial Prohibitin Complex Histone Deacetylase Binding Proteinase Activated Receptor Binding Oligodendrocyte Apoptotic Process	Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Lymphocyte Activation B Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Somatic Cell DNA Recombination Immune Effector Process Regulation Of Immunoglobulin Production Somatic Diversification Of Immunoglobulins Positive Regulation Of Cell Activation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Acute Inflammatory Response Response To Bacterium Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Gene Expression CD40 Receptor Binding Positive Regulation Of Anion Channel Activity Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Positive Regulation Of Detection Of Glucose Regulation Of Lymphocyte Activation Inflammatory Response Lymphocyte Activation Involved In Immune Response Positive Regulation Of Monoatomic Anion Transport Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Male Meiosis Chromosome Segregation MutLalpha Complex Leukocyte Activation Involved In Immune Response Regulation Of Cell Activation Positive Regulation Of Enamel Mineralization Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Cell Activation Involved In Immune Response Antimicrobial Humoral Response Regulation Of Immune System Process Transepithelial Water Transport Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Response To Symbiotic Bacterium Response To Symbiont Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process
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