IGKC and IGHG1

Number of citations of the paper that reports this interaction (PubMedID 11183784)
0

Data Source:
HPRD (in vitro)

		IGKC	IGHG1
Description		immunoglobulin kappa constant	immunoglobulin heavy constant gamma 1 (G1m marker)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Extracellular Exosome IgG Immunoglobulin Complex IgD Immunoglobulin Complex IgE Immunoglobulin Complex IgA Immunoglobulin Complex IgM Immunoglobulin Complex Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle
	Molecular Function	Antigen Binding	Antigen Binding Protein Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Immunoglobulin Mediated Immune Response B Cell Receptor Signaling Pathway	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Complement-dependent Cytotoxicity
Pathways
Drugs
Diseases
GWAS			Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)
Interacting Genes		7 interacting genes: CD40LG CFTR IGHG1 MLH1 PLGLB2 REG3A SMARCD1	9 interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7
Entrez ID		3514	3500
HPRD ID		00921	11755
Ensembl ID		ENSG00000211592	ENSG00000211896
Uniprot IDs
PDB IDs
Enriched GO Terms of Interacting Partners?		Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Lymphocyte Activation B Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Somatic Cell DNA Recombination Immune Effector Process Regulation Of Immunoglobulin Production Somatic Diversification Of Immunoglobulins Positive Regulation Of Cell Activation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Acute Inflammatory Response Response To Bacterium Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Gene Expression CD40 Receptor Binding Positive Regulation Of Anion Channel Activity Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Positive Regulation Of Detection Of Glucose Regulation Of Lymphocyte Activation Inflammatory Response Lymphocyte Activation Involved In Immune Response Positive Regulation Of Monoatomic Anion Transport Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Male Meiosis Chromosome Segregation MutLalpha Complex Leukocyte Activation Involved In Immune Response Regulation Of Cell Activation Positive Regulation Of Enamel Mineralization Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Cell Activation Involved In Immune Response Antimicrobial Humoral Response Regulation Of Immune System Process Transepithelial Water Transport Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Response To Symbiotic Bacterium Response To Symbiont Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process	Immune Effector Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity IgG Receptor Activity Antibody-dependent Cellular Cytotoxicity Hypersensitivity IgG Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Regulation Of Immune System Process Leukocyte Mediated Immunity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Regulation Of DNA-binding Transcription Factor Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Inflammatory Response Immune System Process Somatic Recombination Of Immunoglobulin Gene Segments Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immune Response Response To Stress DNA Recombination Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Metabolic Process Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Adaptive Immune Response Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process B Cell Activation Involved In Immune Response External Side Of Plasma Membrane Leukocyte Mediated Cytotoxicity Regulation Of Protein Stability Negative Regulation Of Proteolysis Involved In Protein Catabolic Process CD40 Receptor Binding Regulation Of Immune Response Immune Response-regulating Signaling Pathway Low-affinity IgG Receptor Activity Immune Receptor Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Autophagosome Assembly Protein Deubiquitination Positive Regulation Of Immune System Process Autophagosome Organization
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