CD40LG

Description		CD40 ligand
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Immune System Process Inflammatory Response Immune Response Cell Communication Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression CD40 Signaling Pathway Signaling Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Isotype Switching Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Ruplizumab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		CD40 ligand levels ( 25147954) Lymphocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Novel Interacting Genes		7 novel interacting genes: CD40 CD5L IGHG1 IGKC PHB1 RNF128 TP53
Interacting Genes		7 interacting genes: CD40 CD5L IGHG1 IGKC PHB1 RNF128 TP53
Entrez ID		959
HPRD ID		02311
Ensembl ID		ENSG00000102245
Uniprot IDs		P29965
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB 6W9G 7SGM
Enriched GO Terms of Interacting Partners?		Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Binding B Cell Mediated Immunity Adaptive Immune Response IgG Immunoglobulin Complex Regulation Of Immune Response Immune System Process Blood Microparticle Immune Response-regulating Signaling Pathway Immune Effector Process Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Immunoglobulin Complex Regulation Of Complement Activation Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Humoral Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immunoglobulin Production Immune Response-activating Signaling Pathway Positive Regulation Of Complement-dependent Cytotoxicity Enzyme Binding Positive Regulation Of Immune System Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Complement Component C3a Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Immunoglobulin Production Activation Of Immune Response Lymphocyte Activation Defense Response Inflammatory Response Positive Regulation Of Programmed Cell Death Immune Response Leukocyte Activation Lymphocyte Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Mononuclear Cell Proliferation Response To Cobalamin Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Mitochondrial Prohibitin Complex Histone Deacetylase Binding Proteinase Activated Receptor Binding Oligodendrocyte Apoptotic Process
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