MED27 and MED22

Number of citations of the paper that reports this interaction (PubMedID 12584197)
0

Data Source:
HPRD (in vitro)

		MED27	MED22
Description		mediator complex subunit 27	mediator complex subunit 22
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Cytoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Gout (normal type) ( 32238385) Triglyceride levels ( 32203549)	Blood protein levels in cardiovascular risk ( 28369058) Malaria ( 31844061)
Interacting Genes		12 interacting genes: AFP ARFGAP1 CEBPA ESR1 FBXO7 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5	13 interacting genes: CEBPA FBXO7 GOLM1 HGS MED11 MED17 MED27 MED30 MED8 MED9 NTAQ1 THOC7 TXNDC9
Entrez ID		9442	6837
HPRD ID		05438	01713
Ensembl ID		ENSG00000160563	ENSG00000148297
Uniprot IDs		Q6P2C8	Q15528
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Regulation Of DNA-templated Transcription Initiation Mediator Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein-DNA Complex Assembly Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stem Cell Proliferation Protein-containing Complex Organization Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ovulation Cycle Process Steroid Metabolic Process Transcription Regulator Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Gene Expression Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Somatic Stem Cell Population Maintenance Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process	Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Ubiquitin Ligase Complex Protein-DNA Complex Assembly Transcription Coregulator Activity Protein Ubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Population Maintenance Post-translational Protein Modification Nuclear Vitamin D Receptor Binding Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Stem Cell Population Maintenance Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Nuclear Thyroid Hormone Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Organization Nucleoplasm Transcription Initiation At RNA Polymerase II Promoter Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein-N-terminal Glutamine Amidohydrolase Activity Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Response To Vitamin B2
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