MED27 and SOX5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MED27	SOX5
Description		mediator complex subunit 27	SRY-box transcription factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Mediator Complex Core Mediator Complex	Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Cartilage Development Asymmetric Neuroblast Division Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Gout (normal type) ( 32238385) Triglyceride levels ( 32203549)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) AIDS ( 19754311) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 29325848) Body mass index ( 25673413) Chronic back pain ( 30261039) Chronotype ( 30696823) Creatinine levels ( 29403010) Depression ( 29700475) Glomerular filtration rate ( 29403010) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Juvenile osteochondritis dissecans ( 26422391) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mortality in sepsis ( 27639821) Multisite chronic pain ( 33830993) Non-obstructive azoospermia ( 22197933) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Pelvic organ prolapse (moderate/severe) ( 26545240) PR interval ( 30046033 20062060 29127183 32439900) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656) Systemic sclerosis ( 21779181) Systolic blood pressure ( 30224653) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: AFP ARFGAP1 CEBPA ESR1 FBXO7 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5	46 interacting genes: ABCC9 APP ARID5A BCAT1 BIRC7 C2CD5 CAMK2A CBX8 CDC23 CDC25A CDK6 CRX FOXP1 FOXP2 FOXP4 FTH1 FXR1 HNF1B IRAG2 KAT5 KIFC3 LMO1 LMO2 MAGED1 MED27 MORN3 MSX2 NFIC NFIX PIAS2 PRR20A RNF4 RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TENT5B TEX11 TRAF2 TTC1 UBE2I UQCRFS1 ZBTB26 ZNF581
Entrez ID		9442	6660
HPRD ID		05438	18086
Ensembl ID		ENSG00000160563	ENSG00000134532
Uniprot IDs		Q6P2C8	F5H0I3 P35711 T2CYZ2
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Regulation Of DNA-templated Transcription Initiation Mediator Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein-DNA Complex Assembly Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stem Cell Proliferation Protein-containing Complex Organization Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ovulation Cycle Process Steroid Metabolic Process Transcription Regulator Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Gene Expression Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Somatic Stem Cell Population Maintenance Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process	Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Chromatin Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Heteromeric SMAD Protein Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Nucleoplasm Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Mesonephric Tubule Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mesonephric Epithelium Development I-SMAD Binding Cardiac Conduction System Development Stem Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Transcription Factor Binding Osteoblast Fate Commitment Striated Muscle Tissue Development Identical Protein Binding Epithelium Development Kidney Epithelium Development Positive Regulation Of RNA Metabolic Process Mitotic Cell Cycle Phase Transition Muscle Tissue Development
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