MED22 and MED17

Number of citations of the paper that reports this interaction (PubMedID 12584197)
0

Data Source:
HPRD (in vitro)

		MED22	MED17
Description		mediator complex subunit 22	mediator complex subunit 17
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mediator Complex Core Mediator Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Malaria ( 31844061)
Interacting Genes		13 interacting genes: CEBPA FBXO7 GOLM1 HGS MED11 MED17 MED27 MED30 MED8 MED9 NTAQ1 THOC7 TXNDC9	17 interacting genes: BCL6 CEBPA CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49
Entrez ID		6837	9440
HPRD ID		01713	04816
Ensembl ID		ENSG00000148297	ENSG00000042429
Uniprot IDs		Q15528	Q9NVC6
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Ubiquitin Ligase Complex Protein-DNA Complex Assembly Transcription Coregulator Activity Protein Ubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Population Maintenance Post-translational Protein Modification Nuclear Vitamin D Receptor Binding Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Stem Cell Population Maintenance Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Nuclear Thyroid Hormone Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Organization Nucleoplasm Transcription Initiation At RNA Polymerase II Promoter Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein-N-terminal Glutamine Amidohydrolase Activity Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Response To Vitamin B2	Nucleoplasm Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Sequence-specific DNA Binding Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Cell Growth Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Protein-DNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Negative Regulation Of Growth Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Nuclear Receptor Activity Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Elongation
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