CNOT8 and CNOT6

Number of citations of the paper that reports this interaction (PubMedID 10637334)
44

Data Source:
HPRD (two hybrid)

		CNOT8	CNOT6
Description		CCR4-NOT transcription complex subunit 8	CCR4-NOT transcription complex subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	3'-5'-RNA Exonuclease Activity Transcription Coactivator Activity RNA Binding Catalytic Activity Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Catabolic Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of DNA-templated Transcription Nuclear-transcribed MRNA Catabolic Process, No-go Decay
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Ovarian cancer ( 30557369) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		11 interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2	5 interacting genes: CNOT4 CNOT7 CNOT8 OBI1 PABPC1
Entrez ID		9337	57472
HPRD ID		07225	12341
Ensembl ID		ENSG00000155508	ENSG00000113300
Uniprot IDs		B7Z9U0 E5RHL9 Q9UFF9	Q9ULM6
PDB IDs			7AX1
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process Negative Regulation Of Gene Expression Poly(A)-specific Ribonuclease Activity Regulation Of Translation RNA Catabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Stem Cell Population Maintenance Regulation Of Developmental Process Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening P-body Positive Regulation Of Organelle Assembly Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Cytoplasm Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Megakaryocyte Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Organelle Assembly GATOR1 Complex Binding	CCR4-NOT Complex Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Catabolic Process CCR4-NOT Core Complex Positive Regulation Of MRNA Catabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nucleic Acid Binding Positive Regulation Of MRNA Metabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulatory NcRNA-mediated Gene Silencing Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Macromolecule Catabolic Process Regulation Of MRNA Metabolic Process Exonuclease Activity Negative Regulation Of Gene Expression Positive Regulation Of Viral Process Regulation Of Translation Protein Autoubiquitination RNA Metabolic Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule RNA Binding MRNA Destabilization P-body Positive Regulation Of Catabolic Process RNA Destabilization Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulation Of Viral Process Catabolic Process Nucleic Acid Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MCRD-mediated MRNA Stability Complex
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