CNOT8

Description		CCR4-NOT transcription complex subunit 8
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Catabolic Process
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)
Novel Interacting Genes		11 novel interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2
Interacting Genes		11 interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2
Entrez ID		9337
HPRD ID		07225
Ensembl ID		ENSG00000155508
Uniprot IDs		B7Z9U0 E5RHL9 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process Negative Regulation Of Gene Expression Poly(A)-specific Ribonuclease Activity Regulation Of Translation RNA Catabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Stem Cell Population Maintenance Regulation Of Developmental Process Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening P-body Positive Regulation Of Organelle Assembly Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Cytoplasm Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Megakaryocyte Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Organelle Assembly GATOR1 Complex Binding
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