CNOT8 and TOB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CNOT8	TOB2
Description		CCR4-NOT transcription complex subunit 8	transducer of ERBB2, 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding Nuclear Vitamin D Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Catabolic Process	Female Gamete Generation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278) Vitiligo ( 22561518)
Interacting Genes		11 interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2	7 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 PABPC1 RPS6KA1 TMEM132D
Entrez ID		9337	10766
HPRD ID		07225	09583
Ensembl ID		ENSG00000155508	ENSG00000183864
Uniprot IDs		B7Z9U0 E5RHL9 Q9UFF9	Q14106
PDB IDs
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process Negative Regulation Of Gene Expression Poly(A)-specific Ribonuclease Activity Regulation Of Translation RNA Catabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Stem Cell Population Maintenance Regulation Of Developmental Process Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening P-body Positive Regulation Of Organelle Assembly Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Cytoplasm Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Megakaryocyte Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Organelle Assembly GATOR1 Complex Binding	Regulation Of Translation Positive Regulation Of MRNA Catabolic Process CCR4-NOT Complex CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulatory NcRNA-mediated Gene Silencing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Exonuclease Activity Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule MRNA Destabilization P-body RNA Destabilization MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Catabolic Process Nucleic Acid Binding Post-transcriptional Gene Silencing Regulation Of Viral Process MRNA Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Protein Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation MRF Binding MCRD-mediated MRNA Stability Complex Ribosomal Protein S6 Kinase Activity Hepatocyte Proliferation PiRNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization
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