SRSF11 and TNFSF15

		SRSF11	TNFSF15
Description		serine and arginine rich splicing factor 11	TNF superfamily member 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	MRNA Processing RNA Splicing	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	TNFs bind their physiological receptors
Drugs
Diseases			Crohn's disease
GWAS			Asthma ( 32296059) Asthma (childhood onset) ( 34022066) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 32581322 30500874 23266558 26891255) Inflammatory bowel disease ( 18758464 27569725 23128233) Leprosy ( 25642632 20018961) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28062665 28425483 23000144 30643196) Ulcerative colitis ( 21297633 20848476) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		34 interacting genes: ARL6IP4 ATP5F1D CDK6 CSNK2A1 DACH1 DDOST DUSP29 ETS1 GATC HNRNPLL HYI LNX2 MDM2 MEOX2 OGT PAK5 PAX6 PIN1 PUF60 RAB2B RNPS1 SDCBP SREK1 SRPK2 SRRM4 SRSF1 SRSF2 TANK THAP11 TNFSF15 TOP1 U2AF2 ZC3HAV1 ZNF385C	9 interacting genes: DELEC1 FKBP15 OAT PTBP3 SLC46A2 SRSF11 TMEM126A TNFRSF25 TNFRSF6B
Entrez ID		9295	9966
HPRD ID		03599	04956
Ensembl ID		ENSG00000116754	ENSG00000181634
Uniprot IDs		Q05519 Q5T757 Q5T760	A0A0U5JA19 O95150
PDB IDs			2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing MRNA Processing MRNA Metabolic Process RNA Metabolic Process RNA Splicing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleic Acid Metabolic Process RNA Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Splicing Regulation Of Cell Motility Regulation Of Locomotion Protein Binding Nuclear Body Organization Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Chromatin DNA Binding Negative Regulation Of Macromolecule Metabolic Process Exon-exon Junction Complex RNA Splicing, Via Transesterification Reactions Positive Regulation Of Type I Interferon Production Sin3-type Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Negative Regulation Of MRNA Metabolic Process Alternative MRNA Splicing, Via Spliceosome	L-arginine Catabolic Process To L-glutamate Ornithine Aminotransferase Activity L-arginine Catabolic Process To Proline Via Ornithine
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