SRSF11 and ZC3HAV1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SRSF11	ZC3HAV1
Description		serine and arginine rich splicing factor 11	zinc finger CCCH-type containing, antiviral 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Cytoplasm Lysosome Late Endosome Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding	RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding NAD+ Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	MRNA Processing RNA Splicing	Immune System Process Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of MRNA Catabolic Process Protein Poly-ADP-ribosylation Positive Regulation Of RIG-I Signaling Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS			Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		34 interacting genes: ARL6IP4 ATP5F1D CDK6 CSNK2A1 DACH1 DDOST DUSP29 ETS1 GATC HNRNPLL HYI LNX2 MDM2 MEOX2 OGT PAK5 PAX6 PIN1 PUF60 RAB2B RNPS1 SDCBP SREK1 SRPK2 SRRM4 SRSF1 SRSF2 TANK THAP11 TNFSF15 TOP1 U2AF2 ZC3HAV1 ZNF385C	11 interacting genes: AKT1 APP FOXP1 KRTAP10-6 MDFI NXF1 OGT PCBP3 SNRPA SRSF11 USP7
Entrez ID		9295	56829
HPRD ID		03599	09534
Ensembl ID		ENSG00000116754	ENSG00000105939
Uniprot IDs		Q05519 Q5T757 Q5T760	C9J6P4 Q7Z2W4
PDB IDs			2X5Y 4X52 6UEI 6UEJ 7KZH 7TGQ 9BGL
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing MRNA Processing MRNA Metabolic Process RNA Metabolic Process RNA Splicing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleic Acid Metabolic Process RNA Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Splicing Regulation Of Cell Motility Regulation Of Locomotion Protein Binding Nuclear Body Organization Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Chromatin DNA Binding Negative Regulation Of Macromolecule Metabolic Process Exon-exon Junction Complex RNA Splicing, Via Transesterification Reactions Positive Regulation Of Type I Interferon Production Sin3-type Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Negative Regulation Of MRNA Metabolic Process Alternative MRNA Splicing, Via Spliceosome	TORC1 Signaling TOR Signaling Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Identical Protein Binding Cellular Response To Nerve Growth Factor Stimulus Nucleic Acid Binding Response To Nerve Growth Factor Nucleus Negative Regulation Of Gene Expression Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of TRNA Methylation Maintenance Of Protein Location In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly
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