TNFSF15 and OAT

		TNFSF15	OAT
Description		TNF superfamily member 15	ornithine aminotransferase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Ornithine Aminotransferase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Visual Perception L-arginine Catabolic Process To Proline Via Ornithine L-arginine Catabolic Process To L-glutamate L-proline Biosynthetic Process
Pathways		TNFs bind their physiological receptors	Glutamate and glutamine metabolism
Drugs			Pyridoxal phosphate Ornithine Gabaculine Canaline
Diseases		Crohn's disease	Ornithinaemia
GWAS		Asthma ( 32296059) Asthma (childhood onset) ( 34022066) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 32581322 30500874 23266558 26891255) Inflammatory bowel disease ( 18758464 27569725 23128233) Leprosy ( 25642632 20018961) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28062665 28425483 23000144 30643196) Ulcerative colitis ( 21297633 20848476) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		9 interacting genes: DELEC1 FKBP15 OAT PTBP3 SLC46A2 SRSF11 TMEM126A TNFRSF25 TNFRSF6B	9 interacting genes: FGFR2 LCOR NUDT3 OGT PDE4B RSPH1 SLC35F6 TNFSF15 UBQLN4
Entrez ID		9966	4942
HPRD ID		04956	02021
Ensembl ID		ENSG00000181634	ENSG00000065154
Uniprot IDs		A0A0U5JA19 O95150	A0A140VJQ4 P04181
PDB IDs		2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8	1GBN 1OAT 2BYJ 2BYL 2CAN 2OAT 5VWO 6HX7 6OIA 6V8C 6V8D 7JX9 7LK0 7LK1 7LNM 7LOM 7LON 7T9Z 7TA0 7TA1 7TED 7TEV 7TFP 8EZ1 8V9M
Enriched GO Terms of Interacting Partners?		L-arginine Catabolic Process To L-glutamate Ornithine Aminotransferase Activity L-arginine Catabolic Process To Proline Via Ornithine	Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Cellular Response To Oxygen-containing Compound Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Orbitofrontal Cortex Development Mammary Gland Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Cellular Response To Lipid Excitatory Synapse Branch Elongation Involved In Salivary Gland Morphogenesis Purine Ribonucleotide Catabolic Process Negative Regulation Of Relaxation Of Cardiac Muscle Nucleotide Catabolic Process Purine Nucleotide Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein O-acetylglucosaminyltransferase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Radial Spoke Head 1 Radial Spoke Head 3 Positive Regulation Of Phospholipase Activity Nucleoside Phosphate Catabolic Process Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Fibroblast Growth Factor Receptor Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Forebrain Neuroblast Division Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
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