PDLIM7 and SH3BP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PDLIM7	SH3BP2
Description		PDZ and LIM domain 7	SH3 domain binding protein 2
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GO Annotations	Cellular Component	Stress Fiber Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Heart Development Actin Cytoskeleton Organization Cell Differentiation Muscle Structure Development	Signal Transduction
Pathways		RET signaling
Drugs
Diseases			Cherubism
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hodgkin's lymphoma ( 34216518) Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)
Interacting Genes		64 interacting genes: ABI2 AP5B1 ATOSB BAG3 BSG CATSPER1 CCDC185 CDK12 DDX6 DGCR6 DNER ENKD1 FAM90A1 FNDC11 FRS3 GARIN6 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SNCA SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	32 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70
Entrez ID		9260	6452
HPRD ID		10436	03657
Ensembl ID		ENSG00000196923	ENSG00000087266
Uniprot IDs		Q9NR12	A0A384N6E5 P78314
PDB IDs		2Q3G 7RM8	2CR4 3TWR
Enriched GO Terms of Interacting Partners?		Protein Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Striated Muscle Cell Apoptotic Process Cellular Response To Actinomycin D Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Muscle Cell Apoptotic Process Response To Actinomycin D Protein Kinase C Signaling Cellular Response To UV-C Regulation Of MAPK Cascade Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Transport Regulation Of Protein Metabolic Process Regulation Of Chaperone-mediated Autophagy Regulation Of Programmed Cell Death Histone H3K36me3 Reader Activity Actin Filament Apoptotic Process Regulation Of Gene Expression Cytoplasmic Side Of Plasma Membrane Supramolecular Fiber Organization Negative Regulation Of Catabolic Process Enzyme Binding Programmed Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Cellular Response To Antibiotic Cell Death Negative Regulation Of Programmed Cell Death Mitotic Nuclear Membrane Disassembly Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding CD40 Receptor Complex	Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Regulation Of Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Activation Of Immune Response Cell Motility Plasma Membrane Cell Migration Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Protein Kinase Activity Regulation Of Cell Activation Positive Regulation Of Immune Response T Cell Activation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of Immune Response Immune System Process
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