SH3BP2 and ARHGAP10

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SH3BP2	ARHGAP10
Description		SH3 domain binding protein 2	Rho GTPase activating protein 10
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GO Annotations	Cellular Component		Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Regulation of PAK-2p34 activity by PS-GAP/RHG10 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases		Cherubism
GWAS		Hodgkin's lymphoma ( 34216518) Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)	Atrial fibrillation ( 29892015 30061737) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) QT interval ( 20031603) Resting heart rate ( 27798624) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		32 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	11 interacting genes: ANKS1A ARF6 CDC42 HRAS KLHL20 PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ
Entrez ID		6452	79658
HPRD ID		03657	07949
Ensembl ID		ENSG00000087266	ENSG00000071205
Uniprot IDs		A0A384N6E5 P78314	A0A2X0SFB3 A1A4S6
PDB IDs		2CR4 3TWR	2MIO
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Regulation Of Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Activation Of Immune Response Cell Motility Plasma Membrane Cell Migration Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Protein Kinase Activity Regulation Of Cell Activation Positive Regulation Of Immune Response T Cell Activation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of Immune Response Immune System Process	G Protein Activity Establishment Of Epithelial Cell Polarity Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cytokinesis Substantia Nigra Development Midbody Focal Adhesion Cleavage Furrow Neural Nucleus Development Cell Migration Regulation Of Cytoskeleton Organization Thioesterase Binding Regulation Of Actin Filament Organization Glutamatergic Synapse Small GTPase-mediated Signal Transduction Cell Motility Regulation Of Cytokinesis Nucleotide Binding Positive Regulation Of Cell Division Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction GTPase Activity Regulation Of Cell Projection Organization Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity GTP Binding Regulation Of Supramolecular Fiber Organization Cytosol Ameboidal-type Cell Migration Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Signal Transduction Establishment Or Maintenance Of Cell Polarity Apoptotic Process Cell Junction Organization Positive Regulation Of Supramolecular Fiber Organization Cell Death Regulation Of Cell Division Programmed Cell Death Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility
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