RASL10B and PAX2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		RASL10B	PAX2
Description		RAS like family 10 member B	paired box 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm Microtubule Organizing Center Protein-containing Complex Protein-DNA Complex Centriolar Satellite
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Atrial Natriuretic Peptide Positive Regulation Of Peptide Hormone Secretion	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Sensory Organ Development Mesodermal Cell Fate Specification Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Cell Differentiation Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Mesenchymal To Epithelial Transition Optic Chiasma Development Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Nephric Duct Formation Ureter Development Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cochlea Development Cochlea Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation
Pathways			Formation of intermediate mesoderm Formation of the nephric duct Formation of the ureteric bud
Drugs
Diseases			Renal coloboma syndrome (RCS); Papillorenal syndrome
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321)	Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30679032) Alzheimer's disease ( 20061627) Bitter alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Diastolic blood pressure ( 27841878) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Systolic blood pressure ( 30578418 28135244 27841878)
Interacting Genes		11 interacting genes: AKT1 APP BAG4 CFTR FGFR2 FGFR4 NDUFS3 NEDD4L PARP1 PAX2 TSG101	29 interacting genes: BBS1 BBS2 BBS4 BBS7 BEX1 BLID CDK2 GLCE HNF1B ID2 IL13RA2 KLK6 KLK9 MAPK8 MAPK8IP1 MRC2 NFIC NFIX NSD3 PAXIP1 PRDM14 RASL10B RB1 SFRP2 SNAI1 TRIM25 VHL VPS45 WT1
Entrez ID		91608	5076
HPRD ID		15215	01330
Ensembl ID		ENSG00000270885	ENSG00000075891
Uniprot IDs		Q96S79	A0A9L9PXU6 A0A9L9PYK3 Q02962 Q5SZP1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Regulation Of Protein Localization Response To Growth Factor Response To Nerve Growth Factor Regulation Of Membrane Potential Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Response To Lipid Cellular Response To Nerve Growth Factor Stimulus Fibroblast Growth Factor Receptor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport Response To Alcohol Regulation Of Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Developmental Growth Protein-folding Chaperone Binding Regulation Of Small Molecule Metabolic Process Protein Homodimerization Activity Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Protein Autophosphorylation Protein-containing Complex Endosome Cellular Developmental Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Enzyme Binding Epithelial Cell Differentiation Fibroblast Growth Factor Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Transport Regulation Of Protein Localization To Nucleus Chemical Homeostasis Heparin Binding Axonogenesis Morphogenesis Of Embryonic Epithelium Positive Regulation Of Developmental Growth Positive Regulation Of Endocytosis Cellular Response To Lipid Cellular Response To Metal Ion Positive Regulation Of Signal Transduction 14-3-3 Protein Binding Positive Regulation Of ERK1 And ERK2 Cascade Epithelial Tube Formation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Developmental Process	BBSome Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Metabolic Process Regulation Of Cilium Movement Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Striatum Development Ciliary Membrane Regulation Of Cilium Beat Frequency Fat Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Brain Morphogenesis Digestive Tract Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Melanosome Transport Positive Regulation Of Biosynthetic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Tube Morphogenesis Negative Regulation Of RNA Metabolic Process Pigment Granule Localization Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Epithelial Tube Morphogenesis
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