PAX2 and GLCE

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		PAX2	GLCE
Description		paired box 2	glucuronic acid epimerase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Organizing Center Protein-containing Complex Protein-DNA Complex Centriolar Satellite	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Calcium Ion Binding Isomerase Activity Racemase And Epimerase Activity, Acting On Carbohydrates And Derivatives Protein Homodimerization Activity Metal Ion Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity
	Biological Process	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Sensory Organ Development Mesodermal Cell Fate Specification Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Cell Differentiation Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Mesenchymal To Epithelial Transition Optic Chiasma Development Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Nephric Duct Formation Ureter Development Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cochlea Development Cochlea Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation	Positive Regulation Of Cell Population Proliferation Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Proteoglycan Biosynthetic Process Negative Regulation Of Cell Projection Organization Positive Regulation Of SMAD Protein Signal Transduction
Pathways		Formation of intermediate mesoderm Formation of the nephric duct Formation of the ureteric bud	HS-GAG biosynthesis
Drugs
Diseases		Renal coloboma syndrome (RCS); Papillorenal syndrome
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30679032) Alzheimer's disease ( 20061627) Bitter alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Diastolic blood pressure ( 27841878) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Systolic blood pressure ( 30578418 28135244 27841878)	Blood protein levels ( 30072576)
Interacting Genes		29 interacting genes: BBS1 BBS2 BBS4 BBS7 BEX1 BLID CDK2 GLCE HNF1B ID2 IL13RA2 KLK6 KLK9 MAPK8 MAPK8IP1 MRC2 NFIC NFIX NSD3 PAXIP1 PRDM14 RASL10B RB1 SFRP2 SNAI1 TRIM25 VHL VPS45 WT1	12 interacting genes: BAG4 BCAR3 CASP8 ERBB2 ESR1 FBXO7 FGFR2 FGFR4 NMB PAX2 PPM1D RB1CC1
Entrez ID		5076	26035
HPRD ID		01330	07020
Ensembl ID		ENSG00000075891	ENSG00000138604
Uniprot IDs		A0A9L9PXU6 A0A9L9PYK3 Q02962 Q5SZP1	O94923
PDB IDs			6HZZ 6I01 6I02
Enriched GO Terms of Interacting Partners?		BBSome Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Metabolic Process Regulation Of Cilium Movement Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Striatum Development Ciliary Membrane Regulation Of Cilium Beat Frequency Fat Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Brain Morphogenesis Digestive Tract Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Melanosome Transport Positive Regulation Of Biosynthetic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Tube Morphogenesis Negative Regulation Of RNA Metabolic Process Pigment Granule Localization Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Epithelial Tube Morphogenesis	Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Prostate Epithelial Cord Elongation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Fibroblast Growth Factor Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Prostate Gland Growth Regulation Of Catalytic Activity Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Signal Transduction Branch Elongation Of An Epithelium Regulation Of MAPK Cascade Stem Cell Differentiation Positive Regulation Of Metabolic Process Axis Elongation Regulation Of Metabolic Process Protein Tyrosine Kinase Activity Fibroblast Growth Factor Binding Prostate Gland Epithelium Morphogenesis Response To Lipid Morphogenesis Of A Branching Epithelium Morphogenesis Of Embryonic Epithelium Morphogenesis Of A Branching Structure Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epithelial Tube Formation Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Organ Growth Positive Regulation Of Macromolecule Biosynthetic Process Response To Epidermal Growth Factor Regulation Of Morphogenesis Of A Branching Structure Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow
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