PCSK7 and PMCH

Number of citations of the paper that reports this interaction (PubMedID 10037747)
0

Data Source:
HPRD (in vivo)

		PCSK7	PMCH
Description		proprotein convertase subtilisin/kexin type 7	pro-melanin concentrating hormone
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Endomembrane System Membrane	Extracellular Region Nucleus Synapse
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Proteolysis Protein Processing Peptide Hormone Processing	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic
Pathways		Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 24507774 31170924) Iron status biomarkers ( 21149283) Refractive error ( 32231278) Triglyceride levels ( 26763881) Triglycerides ( 24507774)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		7 interacting genes: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP TRIM54	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		9159	5367
HPRD ID		05339	01459
Ensembl ID		ENSG00000160613	ENSG00000183395
Uniprot IDs		Q16549	P20382
PDB IDs			8WSS 8WST 8WWK 8WWL 8WWM 8WWN
Enriched GO Terms of Interacting Partners?		MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Cytoplasmic Translation MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability CRD-mediated MRNA Stability Complex Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Catabolic Process Regulation Of Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Binding Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of Protein Metabolic Process MRNA Binding Nucleobase-containing Compound Catabolic Process Macromolecule Catabolic Process Hepatocyte Dedifferentiation Ribonucleoprotein Complex Cellular Response To Putrescine Regulation Of Protein Folding In Endoplasmic Reticulum Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Catalytic Step 2 Spliceosome Negative Regulation Of Gene Expression Cytoplasmic Stress Granule Positive Regulation Of Gene Expression Circadian Regulation Of Translation Cerebellum Structural Organization Negative Regulation Of Synaptic Transmission, Dopaminergic Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle
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