PMCH and MCHR1

Number of citations of the paper that reports this interaction (PubMedID 11478907)
0

Data Source:
HPRD (in vitro)

		PMCH	MCHR1
Description		pro-melanin concentrating hormone	melanin concentrating hormone receptor 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Synapse	Plasma Membrane Cilium Membrane Neuron Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding	G Protein-coupled Receptor Activity Signaling Receptor Binding Neuropeptide Receptor Activity Melanin-concentrating Hormone Receptor Activity Hormone Binding Neuropeptide Binding
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic	Generation Of Precursor Metabolites And Energy Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Feeding Behavior Positive Regulation Of Calcium Ion Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium
Drugs			Haloperidol
Diseases
GWAS		Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Feeling worry ( 29500382) Large artery stroke ( 28265093) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 28991256)
Interacting Genes		10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	4 interacting genes: EP300 HUNK PMCH ZMYND19
Entrez ID		5367	2847
HPRD ID		01459	11874
Ensembl ID		ENSG00000183395	ENSG00000128285
Uniprot IDs		P20382	Q99705
PDB IDs		8WSS 8WST 8WWK 8WWL 8WWM 8WWN	8WSS 8WWH 8WWI 8WWJ 8WWK 8WWL 8WWM 8WWN 8YNT
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle	Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Negative Regulation Of Synaptic Transmission, Dopaminergic N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Protein Oligomerization L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Tubulin Deacetylation Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Regulation Of Synaptic Transmission, Dopaminergic Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Positive Regulation Of Cell Fate Commitment T-helper 17 Cell Lineage Commitment STAT Family Protein Binding Histone H4 Acetyltransferase Activity TORC2 Signaling Regulation Of Cellular Response To Heat Response To L-leucine Negative Regulation Of Gluconeogenesis Host-mediated Activation Of Viral Transcription Tricarboxylic Acid Metabolic Process T-helper Cell Lineage Commitment Acetyltransferase Activity
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