DERL3 and ULBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DERL3	ULBP2
Description		derlin 3	UL16 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding	Protein Binding GPI Anchor Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity
	Biological Process	Protein N-linked Glycosylation Via Asparagine Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Signal Transduction Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2	4 interacting genes: DERL3 PDGFRA SYNE1 YIPF6
Entrez ID		91319	80328
HPRD ID		13139	16143
Ensembl ID		ENSG00000099958	ENSG00000131015
Uniprot IDs		Q96Q80	Q9BZM5
PDB IDs			8IMX 8IMY
Enriched GO Terms of Interacting Partners?			Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Alpha-receptor Activity Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Receptor-ligand Complex Nuclear Matrix Anchoring At Nuclear Membrane Vascular Endothelial Growth Factor Binding Nuclear Matrix Organization Glomerular Capillary Formation Luteinization Protein-containing Complex Binding Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Binding Leydig Cell Differentiation Golgi Apparatus Regulation Of Mesenchymal Stem Cell Differentiation Meiotic Nuclear Membrane Microtubule Tethering Complex Cytoskeleton-nuclear Membrane Anchor Activity Signal Recognition Particle Binding Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Exit From Endoplasmic Reticulum Golgi Trans Cisterna Intestinal Epithelial Cell Development Golgi Medial Cisterna Regulation Of Retrograde Protein Transport, ER To Cytosol Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Columnar/cuboidal Epithelial Cell Development Male Genitalia Development Lamin Binding Embryonic Digestive Tract Morphogenesis White Fat Cell Differentiation Negative Regulation Of Platelet Activation Vascular Endothelial Growth Factor Signaling Pathway Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Exit From Endoplasmic Reticulum Reproductive System Development Adrenal Gland Development Female Gonad Development Maintenance Of Protein Location In Nucleus
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