ULBP2 and SYNE1

		ULBP2	SYNE1
Description		UL16 binding protein 2	spectrin repeat containing nuclear envelope protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Side Of Membrane	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane
	Molecular Function	Protein Binding GPI Anchor Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Signal Transduction Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Meiotic synapsis
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
GWAS		Neurological blood protein biomarker levels ( 31320639)	Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 30194396 31249589 31649266)
Interacting Genes		4 interacting genes: DERL3 PDGFRA SYNE1 YIPF6	39 interacting genes: ACTC1 AKAP12 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD GPX2 IL22RA2 ITSN1 IYD LATS1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 NUP43 PCNT RAET1E RAET1L SH3BP5 TNIK TP53RK ULBP1 ULBP2 USP21 USP7 XIAP ZC3H12D
Entrez ID		80328	23345
HPRD ID		16143	09762
Ensembl ID		ENSG00000131015	ENSG00000131018
Uniprot IDs		Q9BZM5	A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91
PDB IDs		8IMX 8IMY	4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Alpha-receptor Activity Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Receptor-ligand Complex Nuclear Matrix Anchoring At Nuclear Membrane Vascular Endothelial Growth Factor Binding Nuclear Matrix Organization Glomerular Capillary Formation Luteinization Protein-containing Complex Binding Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Binding Leydig Cell Differentiation Golgi Apparatus Regulation Of Mesenchymal Stem Cell Differentiation Meiotic Nuclear Membrane Microtubule Tethering Complex Cytoskeleton-nuclear Membrane Anchor Activity Signal Recognition Particle Binding Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Exit From Endoplasmic Reticulum Golgi Trans Cisterna Intestinal Epithelial Cell Development Golgi Medial Cisterna Regulation Of Retrograde Protein Transport, ER To Cytosol Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Columnar/cuboidal Epithelial Cell Development Male Genitalia Development Lamin Binding Embryonic Digestive Tract Morphogenesis White Fat Cell Differentiation Negative Regulation Of Platelet Activation Vascular Endothelial Growth Factor Signaling Pathway Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Exit From Endoplasmic Reticulum Reproductive System Development Adrenal Gland Development Female Gonad Development Maintenance Of Protein Location In Nucleus	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization
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