DERL3 and MELTF

Number of citations of the paper that reports this interaction (PubMedID 16449191)
56

Data Source:
HPRD (in vivo)

		DERL3	MELTF
Description		derlin 3	melanotransferrin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Membrane Recycling Endosome Extracellular Exosome Side Of Membrane
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding	Iron Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Protein N-linked Glycosylation Via Asparagine Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Regulation Of Cell Growth Monoatomic Ion Transport Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)	Malaria ( 31844061)
Interacting Genes		19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2	12 interacting genes: CFTR CYSRT1 DERL1 DERL2 DERL3 EP300 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA
Entrez ID		91319	4241
HPRD ID		13139	01122
Ensembl ID		ENSG00000099958	ENSG00000163975
Uniprot IDs		Q96Q80	P08582 Q53XS6
PDB IDs			6XR0
Enriched GO Terms of Interacting Partners?			Signal Recognition Particle Binding Response To Endoplasmic Reticulum Stress Regulation Of Cellular Localization Negative Regulation Of Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol ERAD Pathway Regulation Of Retrograde Protein Transport, ER To Cytosol Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Negative Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Protein Destabilization Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Early Endosome Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Derlin-1-VIMP Complex Response To Unfolded Protein Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Protein-containing Complex Binding Keratin Filament
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