ACVR1B and TGFBRAP1

Number of citations of the paper that reports this interaction (PubMedID 11278302)
0

Data Source:
HPRD (in vivo)

		ACVR1B	TGFBRAP1
Description		activin A receptor type 1B	transforming growth factor beta receptor associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Receptor Complex Activin Receptor Complex Serine/threonine Protein Kinase Complex	Cytoplasm Endosome Early Endosome Endomembrane System Membrane CORVET Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding I-SMAD Binding	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Regulation Of DNA-templated Transcription Intracellular Protein Transport Autophagy Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs		ATP Fostamatinib
Diseases
GWAS		Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum CC16 levels ( 32839289) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)	AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Gut microbiota relative abundance (Coprococcus) ( 33208821) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011) Walking pace ( 33128006)
Interacting Genes		25 interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SHMT2 SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1 TUBA1A TUBA1C	10 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A EIF4E2 SMAD2 SMAD4 TGFBR1 TGFBR2
Entrez ID		91	9392
HPRD ID		03193	06948
Ensembl ID		ENSG00000135503	ENSG00000135966
Uniprot IDs		P36896	Q8WUH2
PDB IDs		7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of SMAD Protein Signal Transduction Activin Receptor Binding SMAD Protein Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Lung Development Positive Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Mesoderm Formation Nodal Signaling Pathway Gastrulation Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Embryonic Pattern Specification Formation Of Primary Germ Layer Gastrulation With Mouth Forming Second Regionalization Positive Regulation Of Ovulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Growth Factor Activity Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Axis Specification Roof Of Mouth Development Regulation Of Metabolic Process Response To Growth Factor Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Activin Responsive Factor Complex Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Roof Of Mouth Development Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Signaling Pathway In Utero Embryonic Development Chordate Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Cellular Response To Growth Factor Stimulus I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Endocardial Cushion Morphogenesis Positive Regulation Of Developmental Process Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cell Differentiation Heart Development Regionalization Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Ossification Trophoblast Cell Migration Ventricular Septum Morphogenesis Positive Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity Gastrulation Anterior/posterior Pattern Specification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Tissue Morphogenesis Artery Morphogenesis Secondary Palate Development Embryonic Morphogenesis Receptor Complex Anatomical Structure Formation Involved In Morphogenesis Response To Transforming Growth Factor Beta Cardiac Septum Morphogenesis
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