ACVR1B

Description		activin A receptor type 1B
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Receptor Complex Activin Receptor Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding I-SMAD Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs		ATP Fostamatinib
Diseases
GWAS		Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum CC16 levels ( 32839289) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)
Novel Interacting Genes		25 novel interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SHMT2 SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1 TUBA1A TUBA1C
Interacting Genes		25 interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SHMT2 SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1 TUBA1A TUBA1C
Entrez ID		91
HPRD ID		03193
Ensembl ID		ENSG00000135503
Uniprot IDs		P36896
PDB IDs		7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of SMAD Protein Signal Transduction Activin Receptor Binding SMAD Protein Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Lung Development Positive Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Mesoderm Formation Nodal Signaling Pathway Gastrulation Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Embryonic Pattern Specification Formation Of Primary Germ Layer Gastrulation With Mouth Forming Second Regionalization Positive Regulation Of Ovulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Growth Factor Activity Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Axis Specification Roof Of Mouth Development Regulation Of Metabolic Process Response To Growth Factor Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Activin Responsive Factor Complex Cell Differentiation
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