ACVR1B and FKBP1A

Number of citations of the paper that reports this interaction (PubMedID 16720724)
0

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		ACVR1B	FKBP1A
Description		activin A receptor type 1B	FKBP prolyl isomerase 1A
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Receptor Complex Activin Receptor Complex Serine/threonine Protein Kinase Complex	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding I-SMAD Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Calcium Channel Regulator Activity Protein Binding Macrolide Binding FK506 Binding Isomerase Activity Signaling Receptor Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Transmembrane Transporter Binding I-SMAD Binding Activin Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein Maturation Ventricular Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin	mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses
Drugs		ATP Fostamatinib	Pimecrolimus Tacrolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases
GWAS		Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum CC16 levels ( 32839289) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		25 interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SHMT2 SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1 TUBA1A TUBA1C	32 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DCAF11 DHFR ERBB2 ERBB3 ERBB4 FKBP4 FOXJ1 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1
Entrez ID		91	2280
HPRD ID		03193	01741
Ensembl ID		ENSG00000135503	ENSG00000088832
Uniprot IDs		P36896	A0A087WTS4 P62942 Q0VDC6
PDB IDs		7MRZ 7OLY	1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA 6VCU 6YF0 6YF1 6YF2 6YF3 7EPD 7U0T 7U8D 8CHI 8CHJ 8CHK 8CHL 8CHM 8ER6 8ER7 8ERA 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD4 8JGA 8PDF 8POD 8PPZ 8X6P 8XI9 9CHU 9CHV 9CHX
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of SMAD Protein Signal Transduction Activin Receptor Binding SMAD Protein Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Lung Development Positive Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Mesoderm Formation Nodal Signaling Pathway Gastrulation Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Embryonic Pattern Specification Formation Of Primary Germ Layer Gastrulation With Mouth Forming Second Regionalization Positive Regulation Of Ovulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Growth Factor Activity Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Axis Specification Roof Of Mouth Development Regulation Of Metabolic Process Response To Growth Factor Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Activin Responsive Factor Complex Cell Differentiation	Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Positive Regulation Of Multicellular Organismal Process Heart Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Cell Development SMAD Binding Regulation Of Developmental Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Ubiquitin Protein Ligase Binding Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process System Development Positive Regulation Of Lamellipodium Assembly Regulation Of Cell Communication Activin Receptor Activity, Type I Regulation Of Signaling Cellular Component Assembly Signal Transduction Regulation Of Cell Differentiation Regulation Of Superoxide Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Regulation Of Supramolecular Fiber Organization Negative Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction
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