UCN2 and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
40

Data Source:
HPRD (in vitro, in vivo)

		UCN2	CRHR2
Description		urocortin 2	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Dendrite Axon Terminus
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Hormone Binding Corticotropin-releasing Hormone Receptor Binding Corticotropin-releasing Hormone Receptor 2 Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Digestion Hormone-mediated Signaling Pathway Cellular Response To Nutrient Levels	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors)	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827 28067908)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		2 interacting genes: CRHR2 IL10RB	8 interacting genes: APP CRH GCC1 GPR35 MALL UCN UCN2 UCN3
Entrez ID		90226	1395
HPRD ID		16171	03614
Ensembl ID		ENSG00000145040	ENSG00000106113
Uniprot IDs		Q96RP3	A0A090N7T4 Q13324
PDB IDs		2RMG 3N95	3N93 3N95 3N96 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Interleukin-10 Receptor Activity Interleukin-28 Receptor Complex Cellular Response To Corticotropin-releasing Hormone Stimulus Type III Interferon-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cellular Respiration Positive Regulation Of Receptor Signaling Pathway Via STAT Long-term Synaptic Potentiation Axon Terminus Coreceptor Activity Cellular Response To Virus Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway	Corticotropin-releasing Hormone Receptor 2 Binding Varicosity Positive Regulation Of CAMP/PKA Signal Transduction Hormone Activity Corticotropin-releasing Hormone Receptor Binding Regulation Of CAMP/PKA Signal Transduction Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Calcium Ion Transport Positive Regulation Of Corticotropin Secretion G Protein-coupled Receptor Binding Positive Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Positive Regulation Of Fear Response Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Response To Corticosterone Response To Glucocorticoid Response To Pain Perikaryon Hormone-mediated Signaling Pathway Positive Regulation Of Hormone Secretion Response To Auditory Stimulus Response To Corticosteroid Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Response To Immobilization Stress Positive Regulation Of Calcium Ion Import Positive Regulation Of Behavior Digestion Neuropeptide Hormone Activity Regulation Of Peptide Hormone Secretion Response To Steroid Hormone Response To Mineralocorticoid Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Calcium Ion Import Negative Regulation Of Blood Pressure Learning Or Memory Positive Regulation Of Secretion By Cell Regulation Of Transport Axon Terminus Cognition Positive Regulation Of Establishment Of Protein Localization
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