CRHR2 and UCN2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
40

Data Source:
HPRD (in vitro, in vivo)

		CRHR2	UCN2
Description		corticotropin releasing hormone receptor 2	urocortin 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Axon Terminus	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Hormone Binding Corticotropin-releasing Hormone Receptor Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Digestion Hormone-mediated Signaling Pathway Cellular Response To Nutrient Levels
Pathways		G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin	Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Type 2 diabetes ( 24509480 30297969)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827 28067908)
Interacting Genes		8 interacting genes: APP CRH GCC1 GPR35 MALL UCN UCN2 UCN3	2 interacting genes: CRHR2 IL10RB
Entrez ID		1395	90226
HPRD ID		03614	16171
Ensembl ID		ENSG00000106113	ENSG00000145040
Uniprot IDs		A0A090N7T4 Q13324	Q96RP3
PDB IDs		3N93 3N95 3N96 6PB1 7TRY 7TS0	2RMG 3N95
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor 2 Binding Varicosity Positive Regulation Of CAMP/PKA Signal Transduction Hormone Activity Corticotropin-releasing Hormone Receptor Binding Regulation Of CAMP/PKA Signal Transduction Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Calcium Ion Transport Positive Regulation Of Corticotropin Secretion G Protein-coupled Receptor Binding Positive Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Positive Regulation Of Fear Response Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Response To Corticosterone Response To Glucocorticoid Response To Pain Perikaryon Hormone-mediated Signaling Pathway Positive Regulation Of Hormone Secretion Response To Auditory Stimulus Response To Corticosteroid Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Response To Immobilization Stress Positive Regulation Of Calcium Ion Import Positive Regulation Of Behavior Digestion Neuropeptide Hormone Activity Regulation Of Peptide Hormone Secretion Response To Steroid Hormone Response To Mineralocorticoid Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Calcium Ion Import Negative Regulation Of Blood Pressure Learning Or Memory Positive Regulation Of Secretion By Cell Regulation Of Transport Axon Terminus Cognition Positive Regulation Of Establishment Of Protein Localization	Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Interleukin-10 Receptor Activity Interleukin-28 Receptor Complex Cellular Response To Corticotropin-releasing Hormone Stimulus Type III Interferon-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cellular Respiration Positive Regulation Of Receptor Signaling Pathway Via STAT Long-term Synaptic Potentiation Axon Terminus Coreceptor Activity Cellular Response To Virus Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway
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