USP13 and SYCP2

		USP13	SYCP2
Description		ubiquitin specific peptidase 13	synaptonemal complex protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Condensed Chromosome, Centromeric Region Synaptonemal Complex Lateral Element Nucleus Chromosome
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Protein-folding Chaperone Binding Proteasome Binding BAT3 Complex Binding K48-linked Deubiquitinase Activity	DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Proteolysis Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Regulation Of Protein Stability Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway	Apoptotic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Female Meiotic Nuclear Division Fertilization Animal Organ Morphogenesis Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Male Genitalia Morphogenesis Negative Regulation Of Developmental Process Cell Division Meiotic Cell Cycle Negative Regulation Of Reproductive Process
Pathways		Ub-specific processing proteases Regulation of PTEN stability and activity	Meiotic synapsis
Drugs
Diseases
GWAS			Delirium ( 29631748)
Interacting Genes		30 interacting genes: AMFR ATG5 CCND1 CLK3 CSNK2A1 CTNNB1 DAZAP2 DVL1 DYRK1A FNBP1L FUNDC2 G3BP1 GPR160 HSP90AA1 LAPTM5 MDC1 MRPL20 MYO15A S100A9 SIAH2 SPRR2C SYCP2 TOPBP1 TRA2B TRIM55 TRIM63 TWIST1 UBC UBL4A UIMC1	4 interacting genes: HORMAD2 SRPK2 SYCP3 USP13
Entrez ID		8975	10388
HPRD ID		04666	06822
Ensembl ID		ENSG00000058056	ENSG00000196074
Uniprot IDs		A0A0A6YZ17 Q92995	Q9BX26
PDB IDs		2L80 2LBC
Enriched GO Terms of Interacting Partners?		DNA Damage Checkpoint Signaling Protein Modification Process Wnt Signaling Pathway Protein Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Autophagic Cell Death Autophagy Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Intracellular Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Negative Regulation Of Signal Transduction By P53 Class Mediator Post-translational Protein Modification Response To Stress Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Cycle Process Identical Protein Binding Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Stress Granule Assembly Ubiquitin Protein Ligase Binding Regulation Of DNA Metabolic Process Genitalia Morphogenesis Regulation Of Wnt Signaling Pathway Cellular Response To Stress Negative Regulation Of Wnt Signaling Pathway Wnt Signalosome Cardiac Muscle Cell Apoptotic Process Catabolic Process Protein Serine/threonine Kinase Activator Activity Nucleus Aggrephagy Striated Muscle Cell Apoptotic Process Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Protein-containing Complex Macromolecule Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catabolic Process	Synaptonemal Complex Chromosome Meiotic Cell Cycle Nuclear Speck Organization Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination R-loop Processing Meiotic Sister Chromatid Cohesion
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