SYCP2 and SYCP3

Number of citations of the paper that reports this interaction (PubMedID 30657449)
107

Data Source:
BioGRID (two hybrid)

		SYCP2	SYCP3
Description		synaptonemal complex protein 2	synaptonemal complex protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Synaptonemal Complex Lateral Element Nucleus Chromosome	Chromosome, Centromeric Region Synaptonemal Complex Lateral Element Nucleus Chromosome
	Molecular Function	DNA Binding	DNA Binding Protein Binding
	Biological Process	Apoptotic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Female Meiotic Nuclear Division Fertilization Animal Organ Morphogenesis Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Male Genitalia Morphogenesis Negative Regulation Of Developmental Process Cell Division Meiotic Cell Cycle Negative Regulation Of Reproductive Process	Male Meiosis I Spermatid Development Sperm DNA Condensation Cell Division Meiotic Cell Cycle
Pathways		Meiotic synapsis	Meiotic synapsis
Drugs
Diseases			Azoospermia, including: Azoospermia; Azoospermia due to perturbations of meiosis
GWAS		Delirium ( 29631748)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: HORMAD2 SRPK2 SYCP3 USP13	7 interacting genes: C14orf119 CDC37 LIG4 NR2F2 NXF1 PABPC1 SYCP2
Entrez ID		10388	50511
HPRD ID		06822	07265
Ensembl ID		ENSG00000196074	ENSG00000139351
Uniprot IDs		Q9BX26	Q8IZU3
PDB IDs			4CPC
Enriched GO Terms of Interacting Partners?		Synaptonemal Complex Chromosome Meiotic Cell Cycle Nuclear Speck Organization Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination R-loop Processing Meiotic Sister Chromatid Cohesion	Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Fertilization Lymphatic Endothelial Cell Fate Commitment Radial Pattern Formation Male Genitalia Morphogenesis Cytoplasmic Stress Granule HSP90-CDC37 Chaperone Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development DNA-dependent Protein Kinase-DNA Ligase 4 Complex Single Strand Break Repair Immunoglobulin V(D)J Recombination AMP Binding Chordate Embryonic Development Nonhomologous End Joining Complex Nucleotide-excision Repair, DNA Gap Filling In Utero Embryonic Development Lymph Vessel Development Maternal Placenta Development Trophoblast Giant Cell Differentiation Epithelial Cell Fate Commitment Genitalia Morphogenesis Lateral Element Nuclear RNA Export Factor Complex Nuclear Inclusion Body MRNA Binding Transcription Export Complex Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Positive Regulation Of Type 2 Mitophagy Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Translation Activator Activity MCRD-mediated MRNA Stability Complex Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Response To Lithium Ion Interneuron Migration Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
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