LDB1 and ISL1

Number of citations of the paper that reports this interaction (PubMedID 26495868)
47

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LDB1	ISL1
Description		LIM domain binding 1	ISL LIM homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Beta-catenin-TCF Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Enzyme Binding LIM Domain Binding Identical Protein Binding Protein Homodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Nuclear Receptor Binding LIM Domain Binding Nuclear Estrogen Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription By RNA Polymerase II Cell Adhesion Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellum Development Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Head Development	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Heart Morphogenesis Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Axonogenesis Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial To Mesenchymal Transition Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Cell Differentiation Neuron Differentiation Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Mesenchymal Cell Differentiation Stem Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Canonical Wnt Signaling Pathway Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Sinoatrial Node Cell Development Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Import Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs Cardiogenesis Expression and translocation of olfactory receptors	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs Cardiogenesis
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol use disorder (consumption score) ( 30940813) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Childhood ear infection ( 27182965) Classic bladder exstrophy ( 25763902) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Diastolic blood pressure ( 27841878) Emotional lability in attention deficit hyperactivity disorder ( 31085060) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Verbal declarative memory ( 25648963) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		29 interacting genes: ARTN ATXN1 CTDSP1 DNMT3L DSCAM ESR1 IRAK3 ISL1 LCOR LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP UPF1	22 interacting genes: ADCY2 APP CDK6 CDKN2B CRK ESR1 HNF4A ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LMO2 LMX1A NR2F1 PECR PLCG2 RELA RLIM SMAD3 ZNF511
Entrez ID		8861	3670
HPRD ID		09144	02650
Ensembl ID		ENSG00000198728	ENSG00000016082
Uniprot IDs		A0A6E1WJ75 Q86U70	P61371
PDB IDs		2XJY 2XJZ 2YPA 6TYD 7OB5 7OB8 8HIB 8SSU 9F5B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Neuron Projection Guidance Axon Guidance Transcription Regulator Complex Spinal Cord Motor Neuron Cell Fate Specification DNA Binding Cell Differentiation In Spinal Cord Transcription Coregulator Binding Spinal Cord Association Neuron Differentiation Neuron Differentiation Positive Regulation Of Anterior Head Development Central Nervous System Neuron Differentiation Motor Neuron Axon Guidance Neuron Projection Development BHLH Transcription Factor Binding Neuron Fate Specification RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Single-stranded DNA Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Mesendoderm Development Negative Regulation Of RNA Metabolic Process Regionalization Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Vagina Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Transcription Coactivator Binding Central Nervous System Neuron Differentiation Response To Yeast Regulation Of Metabolic Process Cell Differentiation Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Nucleus DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Developmental Process Regulation Of Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation In Spinal Cord
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