ISL1 and ISL2

Number of citations of the paper that reports this interaction (PubMedID 9452425)
0

Data Source:
HPRD (in vivo)

		ISL1	ISL2
Description		ISL LIM homeobox 1	ISL LIM homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Nuclear Receptor Binding LIM Domain Binding Nuclear Estrogen Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Heart Morphogenesis Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Axonogenesis Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial To Mesenchymal Transition Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Cell Differentiation Neuron Differentiation Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Mesenchymal Cell Differentiation Stem Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Canonical Wnt Signaling Pathway Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Sinoatrial Node Cell Development Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Import Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Regulation Of DNA-templated Transcription Axonogenesis Spinal Cord Motor Neuron Cell Fate Specification Visceral Motor Neuron Differentiation Neuron Differentiation Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Peripheral Nervous System Neuron Development
Pathways		Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs Cardiogenesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol use disorder (consumption score) ( 30940813) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Childhood ear infection ( 27182965) Classic bladder exstrophy ( 25763902) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Diastolic blood pressure ( 27841878) Emotional lability in attention deficit hyperactivity disorder ( 31085060) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Verbal declarative memory ( 25648963) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		22 interacting genes: ADCY2 APP CDK6 CDKN2B CRK ESR1 HNF4A ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LMO2 LMX1A NR2F1 PECR PLCG2 RELA RLIM SMAD3 ZNF511	2 interacting genes: ISL1 LHX3
Entrez ID		3670	64843
HPRD ID		02650	11053
Ensembl ID		ENSG00000016082	ENSG00000159556
Uniprot IDs		P61371	Q96A47
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Transcription Coactivator Binding Central Nervous System Neuron Differentiation Response To Yeast Regulation Of Metabolic Process Cell Differentiation Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Nucleus DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Developmental Process Regulation Of Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation In Spinal Cord	Spinal Cord Motor Neuron Cell Fate Specification Neuron Fate Specification Pituitary Gland Development Cell Differentiation In Spinal Cord Cell Fate Specification Central Nervous System Neuron Differentiation Transcription Regulator Complex Neuron Projection Guidance Regionalization Gland Development Transcription Cis-regulatory Region Binding Axon Guidance RNA Polymerase II-specific DNA-binding Transcription Factor Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Visceral Motor Neuron Differentiation Positive Regulation Of Macrophage Colony-stimulating Factor Production Peripheral Nervous System Neuron Axonogenesis Positive Regulation Of Granulocyte Colony-stimulating Factor Production Neuron Differentiation Cardiac Cell Fate Determination Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Sinoatrial Node Cell Development Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Pattern Specification Process Sensory System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Trigeminal Nerve Development Regulation Of Macrophage Colony-stimulating Factor Production Thyroid-stimulating Hormone-secreting Cell Differentiation Sequence-specific DNA Binding LIM Domain Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Neuron Projection Development Positive Regulation Of Interleukin-1 Alpha Production Animal Organ Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Peripheral Nervous System Neuron Development Cardiac Muscle Cell Myoblast Differentiation Regulation Of Cardioblast Proliferation Secondary Heart Field Specification Spinal Cord Association Neuron Differentiation Heart Field Specification Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Cardiac Right Ventricle Morphogenesis Cardioblast Differentiation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Atrial Septum Morphogenesis
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