ISL1 and LMX1A

Number of citations of the paper that reports this interaction (PubMedID 9452425)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		ISL1	LMX1A
Description		ISL LIM homeobox 1	LIM homeobox transcription factor 1 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Nuclear Receptor Binding LIM Domain Binding Nuclear Estrogen Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Heart Morphogenesis Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Axonogenesis Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial To Mesenchymal Transition Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Cell Differentiation Neuron Differentiation Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Mesenchymal Cell Differentiation Stem Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Canonical Wnt Signaling Pathway Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Sinoatrial Node Cell Development Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Import Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Regulation Of Cell Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Central Nervous System Development Memory Locomotory Behavior Regulation Of Gene Expression Dentate Gyrus Development Cerebellum Development Hippocampus Development Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Olfactory Behavior Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation
Pathways		Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs Cardiogenesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol use disorder (consumption score) ( 30940813) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Childhood ear infection ( 27182965) Classic bladder exstrophy ( 25763902) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Diastolic blood pressure ( 27841878) Emotional lability in attention deficit hyperactivity disorder ( 31085060) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Verbal declarative memory ( 25648963) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Age-related hearing impairment ( 34108613) Alcohol consumption (drinks per week) ( 30679032) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Pursuit maintenance gain ( 29064472) Response to acetaminophen (hepatotoxicity) ( 21177773) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Vestibular neuritis ( 30079052)
Interacting Genes		22 interacting genes: ADCY2 APP CDK6 CDKN2B CRK ESR1 HNF4A ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LMO2 LMX1A NR2F1 PECR PLCG2 RELA RLIM SMAD3 ZNF511	5 interacting genes: BMPR2 ISL1 LDB1 LHX3 TCF3
Entrez ID		3670	4009
HPRD ID		02650	02623
Ensembl ID		ENSG00000016082	ENSG00000162761
Uniprot IDs		P61371	Q8TE12
PDB IDs			8IK5 8IKE 8ILW
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Transcription Coactivator Binding Central Nervous System Neuron Differentiation Response To Yeast Regulation Of Metabolic Process Cell Differentiation Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Nucleus DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Developmental Process Regulation Of Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation In Spinal Cord	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Pattern Specification Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Atrial Septum Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of RNA Metabolic Process Outflow Tract Septum Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process BHLH Transcription Factor Binding Neuron Fate Specification Pituitary Gland Development Transcription Cis-regulatory Region Binding Regionalization Cell Differentiation Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II System Development Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Neuron Differentiation Outflow Tract Morphogenesis Cellular Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cardiac Septum Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Fate Specification Cis-regulatory Region Sequence-specific DNA Binding Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lung Development Stem Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis RNA Polymerase II Transcription Regulator Complex Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Activin Receptor Activity, Type II
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