PROM1 and USP11

Number of citations of the paper that reports this interaction (PubMedID 35975322)
64

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, pull down)

		PROM1	USP11
Description		prominin 1	ubiquitin specific peptidase 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Microvillus Cilium Cell Surface Membrane Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Cell Projection Extracellular Exosome Prominosome	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Podocyte Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Proteolysis Protein Deubiquitination
Pathways		Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)
Interacting Genes		6 interacting genes: HDAC6 HK2 PIK3R1 PLEKHA5 SRC USP11	26 interacting genes: BMI1 BRCA2 CBX8 DECR2 DSCAM EIF4B HELLS LIMS1 LLGL1 MBD3 MTA2 NFE2L2 NONO PCGF2 PML PRMT1 PROM1 RANBP9 RELB RNF2 RPS6KB1 RSPH1 SETDB1 SUMO2 TBL3 UBC
Entrez ID		8842	8237
HPRD ID		05079	02081
Ensembl ID		ENSG00000007062	ENSG00000102226
Uniprot IDs		A0A0A0N0M1 O43490	G5E9A6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type 2 Mitophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Autophagy Of Mitochondrion Establishment Of Protein Localization To Organelle Regulation Of D-glucose Import Regulation Of Mitophagy Regulation Of Protein Stability Negative Regulation Of Cell-substrate Adhesion Cellular Response To Hormone Stimulus Negative Regulation Of Cell-matrix Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of Lamellipodium Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Protein Destabilization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Transcription Corepressor Binding Regulation Of Epithelial Cell Migration Cellular Response To Hydrogen Peroxide Regulation Of D-glucose Transmembrane Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Caveola Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Intracellular Glucose Homeostasis Positive Regulation Of Macroautophagy Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Nucleus Protein Deubiquitination Response To Hydrogen Peroxide Positive Regulation Of Catabolic Process Positive Regulation Of Cell Migration Protein Modification By Small Protein Removal Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Nucleoplasm Negative Regulation Of Apoptotic Signaling Pathway Heterochromatin Regulation Of Apoptotic Signaling Pathway Constitutive Heterochromatin Formation Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Chordate Embryonic Development Cellular Response To Methionine Regulation Of DNA-templated Transcription Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Nucleus Response To Methionine Sex Chromatin Regulation Of RNA Biosynthetic Process Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Cytokine Cellular Response To Hydrogen Peroxide Response To Peptide Promoter-specific Chromatin Binding Camera-type Eye Photoreceptor Cell Differentiation Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound
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