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USP11 and PROM1
Number of citations of the paper that reports this interaction (PubMedID
35975322
)
64
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study, pull down)
USP11
PROM1
Description
ubiquitin specific peptidase 11
prominin 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Photoreceptor Outer Segment
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Microvillus
Cilium
Cell Surface
Membrane
Apical Plasma Membrane
Microvillus Membrane
Vesicle
Photoreceptor Outer Segment Membrane
Cell Projection
Extracellular Exosome
Prominosome
Molecular Function
Transcription Corepressor Binding
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Protein Binding
Cholesterol Binding
Actinin Binding
Cadherin Binding
Biological Process
Proteolysis
Protein Deubiquitination
Retina Layer Formation
Photoreceptor Cell Maintenance
Retina Morphogenesis In Camera-type Eye
Camera-type Eye Photoreceptor Cell Differentiation
Podocyte Differentiation
Glomerular Parietal Epithelial Cell Differentiation
Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Stargardt disease (STGD); Fundus flavimaculatus
Retinitis pigmentosa (RP)
Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Intracranial aneurysm (
29531279
)
Pulse pressure (
30224653
)
Self-rated health (
20707712
)
Suicide attempts in depression or bipolar disorder (
24964207
)
Interacting Genes
26 interacting genes:
BMI1
BRCA2
CBX8
DECR2
DSCAM
EIF4B
HELLS
LIMS1
LLGL1
MBD3
MTA2
NFE2L2
NONO
PCGF2
PML
PRMT1
PROM1
RANBP9
RELB
RNF2
RPS6KB1
RSPH1
SETDB1
SUMO2
TBL3
UBC
6 interacting genes:
HDAC6
HK2
PIK3R1
PLEKHA5
SRC
USP11
Entrez ID
8237
8842
HPRD ID
02081
05079
Ensembl ID
ENSG00000102226
ENSG00000007062
Uniprot IDs
G5E9A6
A0A0A0N0M1
O43490
PDB IDs
Enriched GO Terms of Interacting Partners
?
Chromatin Remodeling
PRC1 Complex
Chromatin Organization
PcG Protein Complex
DNA Methylation-dependent Constitutive Heterochromatin Formation
Chromatin Binding
Nucleoplasm
Negative Regulation Of Apoptotic Signaling Pathway
Heterochromatin
Regulation Of Apoptotic Signaling Pathway
Constitutive Heterochromatin Formation
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
RING-like Zinc Finger Domain Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Translational Initiation
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Cellular Response To Nutrient
Chordate Embryonic Development
Cellular Response To Methionine
Regulation Of DNA-templated Transcription
Embryo Development Ending In Birth Or Egg Hatching
Multicellular Organism Development
Nucleus
Response To Methionine
Sex Chromatin
Regulation Of RNA Biosynthetic Process
Heterochromatin Formation
Ubiquitin-protein Transferase Activator Activity
Regulation Of Primary Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Response To Cytokine
Cellular Response To Hydrogen Peroxide
Response To Peptide
Promoter-specific Chromatin Binding
Camera-type Eye Photoreceptor Cell Differentiation
Protein Tag Activity
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Type 2 Mitophagy
Positive Regulation Of Mitophagy
Positive Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Autophagy Of Mitochondrion
Establishment Of Protein Localization To Organelle
Regulation Of D-glucose Import
Regulation Of Mitophagy
Regulation Of Protein Stability
Negative Regulation Of Cell-substrate Adhesion
Cellular Response To Hormone Stimulus
Negative Regulation Of Cell-matrix Adhesion
Substrate Adhesion-dependent Cell Spreading
Regulation Of Lamellipodium Organization
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Lamellipodium Organization
Positive Regulation Of Epithelial Cell Migration
Epidermal Growth Factor Receptor Signaling Pathway
Protein Destabilization
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Transcription Corepressor Binding
Regulation Of Epithelial Cell Migration
Cellular Response To Hydrogen Peroxide
Regulation Of D-glucose Transmembrane Transport
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell-substrate Junction Organization
ERBB Signaling Pathway
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Caveola
Polyubiquitinated Misfolded Protein Transport
Positive Regulation Of Cholangiocyte Proliferation
Intracellular Glucose Homeostasis
Positive Regulation Of Macroautophagy
Positive Regulation Of Cellular Component Biogenesis
Positive Regulation Of Protein Localization To Nucleus
Protein Deubiquitination
Response To Hydrogen Peroxide
Positive Regulation Of Catabolic Process
Positive Regulation Of Cell Migration
Protein Modification By Small Protein Removal
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Cellular Response To Oxidative Stress
Acetylspermidine Deacetylase Activity
Polyamine Deacetylation
Spermidine Deacetylation
Peroxidase Inhibitor Activity
Negative Regulation Of Aggrephagy
Tubulin Deacetylase Activity
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
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Tagcloud (Intersection)
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