PROM1 and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PROM1	PLEKHA5
Description		prominin 1	pleckstrin homology domain containing A5
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Microvillus Cilium Cell Surface Membrane Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Cell Projection Extracellular Exosome Prominosome	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Podocyte Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Reproductive System Development
Pathways		Developmental Lineage of Pancreatic Ductal Cells	Synthesis of PIPs at the plasma membrane
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		6 interacting genes: HDAC6 HK2 PIK3R1 PLEKHA5 SRC USP11	35 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		8842	54477
HPRD ID		05079	09684
Ensembl ID		ENSG00000007062	ENSG00000052126
Uniprot IDs		A0A0A0N0M1 O43490	A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0
PDB IDs			2DKP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type 2 Mitophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Autophagy Of Mitochondrion Establishment Of Protein Localization To Organelle Regulation Of D-glucose Import Regulation Of Mitophagy Regulation Of Protein Stability Negative Regulation Of Cell-substrate Adhesion Cellular Response To Hormone Stimulus Negative Regulation Of Cell-matrix Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of Lamellipodium Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Protein Destabilization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Transcription Corepressor Binding Regulation Of Epithelial Cell Migration Cellular Response To Hydrogen Peroxide Regulation Of D-glucose Transmembrane Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Caveola Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Intracellular Glucose Homeostasis Positive Regulation Of Macroautophagy Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Nucleus Protein Deubiquitination Response To Hydrogen Peroxide Positive Regulation Of Catabolic Process Positive Regulation Of Cell Migration Protein Modification By Small Protein Removal Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly
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