PLEKHA5 and SH3BP5L

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PLEKHA5	SH3BP5L
Description		pleckstrin homology domain containing A5	SH3 binding domain protein 5 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Reproductive System Development	Intracellular Signal Transduction
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Lead levels ( 26025379)
Interacting Genes		35 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	9 interacting genes: CEP57 EMC2 FAM161B NINL PLEKHA5 RAB14 RAB25 SUOX YWHAG
Entrez ID		54477	80851
HPRD ID		09684	13887
Ensembl ID		ENSG00000052126	ENSG00000175137
Uniprot IDs		A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0	Q7L8J4 Q96MW4
PDB IDs		2DKP
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly	Myosin V Binding Sulfite Oxidase Activity Extrinsic Component Of Endoplasmic Reticulum Membrane Fibroblast Growth Factor Receptor Signaling Pathway G Protein Activity Pseudopodium Membrane
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