DEDD2 and CDCA7L

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DEDD2	CDCA7L
Description		death effector domain containing 2	cell division cycle associated 7 like
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Binding
	Biological Process	RNA Processing Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation
Pathways
Drugs
Diseases
GWAS		Meat-related diet ( 32066663)	Breast cancer ( 29059683) Gamma glutamyl transferase levels ( 33339817) Height ( 20189936) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Pre-treatment viral load in HIV-1 infection ( 31219150) Squamous cell lung carcinoma ( 28604730) Urate levels in obese individuals ( 25811787)
Interacting Genes		12 interacting genes: ATG16L1 CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2	68 interacting genes: ABT1 ANKRD1 ANKRD11 ANKRD23 AVPI1 AXIN1 BAG5 BEND7 BRPF1 BYSL CARD9 CAVIN1 CCDC116 CCDC33 CEP70 CTNNBL1 DAXX DEDD2 DMAP1 EIF4A3 FAM217B FAM9B GOLGA2 GPRASP3 HSF2BP ING5 JADE2 KRTAP10-7 LMO1 MCRS1 MDFI MEOX2 MFAP1 MLH1 MORN3 MRPL28 MYC NDUFB7 NOL12 NOP2 PBX1 PBX2 PICK1 PIH1D1 PIP4K2B PPP1R16A PPP1R16B PRDM14 PRPF31 RRP7A SNRNP48 SSX1 SSX2IP STX11 SUV39H1 TADA2A TFPT TNNI1 TRAF3IP3 TRIM42 UBL4A UTP3 VDR ZGPAT ZNF250 ZNF438 ZNF620 ZNF821
Entrez ID		162989	55536
HPRD ID		10868	11481
Ensembl ID		ENSG00000160570	ENSG00000164649
Uniprot IDs		Q8WXF8	A8K8X5 Q96GN5
PDB IDs			5YI9 6EMO
Enriched GO Terms of Interacting Partners?		Ripoptosome CD95 Death-inducing Signaling Complex Death Effector Domain Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Positive Regulation Of Execution Phase Of Apoptosis Cysteine-type Peptidase Activity Execution Phase Of Apoptosis Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Macrophage Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neuron Apoptotic Process Cyclin D2-CDK6 Complex Vacuole-isolation Membrane Contact Site Regulation Of Metabolic Process Positive Regulation Of Gene Expression Mononuclear Cell Differentiation Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Skeletal Myofibril Assembly Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway C-terminal Protein Lipidation Developmental Process Protein-containing Complex Binding Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Autophagosome Assembly Negative Regulation Of Myoblast Fusion Negative Stranded Viral RNA Replication Autophagosome Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Response To Estradiol Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Editing Complex Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Dendrite Extension	Nucleus RRNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding RRNA Processing Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization RNA Metabolic Process Chromatin Remodeling Chromosome Nucleolus Nucleic Acid Metabolic Process RNA Processing Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process SnoRNA Localization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Myosin Phosphatase Regulator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Apoptotic Signaling Pathway MOZ/MORF Histone Acetyltransferase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleolus Spliceosomal Complex Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Skeletal System Morphogenesis DNA Binding Positive Regulation Of Biosynthetic Process Protein-RNA Complex Assembly Titin Binding Regulation Of DNA Replication Dorsal/ventral Axis Specification Regulation Of Signal Transduction By P53 Class Mediator Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Telomere Maintenance In Response To DNA Damage
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