ALDH4A1 and ARG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ALDH4A1	ARG1
Description		aldehyde dehydrogenase 4 family member A1	arginase 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Azurophil Granule Lumen Specific Granule Lumen
	Molecular Function	L-glutamate Gamma-semialdehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding
	Biological Process	Proline Metabolic Process L-proline Catabolic Process L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process	Urea Cycle Adaptive Immune Response Immune System Process Arginine Metabolic Process L-arginine Catabolic Process Response To Nematode Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Glyoxylate metabolism and glycine degradation Proline catabolism	Neutrophil degranulation Urea cycle
Drugs		NADH	Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases		Hyperprolinemia (HP)	Hyperargininemia
GWAS		Alzheimer's disease (survival time) ( 25649651) Anorexia nervosa ( 23568457) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Serum metabolite levels ( 33031748) Type 2 diabetes ( 30054458)
Interacting Genes		3 interacting genes: APP ARG1 OGT	6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Entrez ID		8659	383
HPRD ID		06009	01947
Ensembl ID		ENSG00000159423	ENSG00000118520
Uniprot IDs		A0A024RAC7 P30038	A0A5F9ZH78 P05089
PDB IDs		3V9G 3V9H 3V9I 4OE5 8RKQ 8RKR	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F 7K4G 7K4H 7K4I 7K4J 7K4K 7KLK 7KLL 7KLM 7LEX 7LEY 7LEZ 7LF0 7LF1 7LF2 8AUP 8E5M 8E5N
Enriched GO Terms of Interacting Partners?		Regulation Of Glycolytic Process Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Gene Expression Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Neutrophil Mediated Killing Of Fungus Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Protein O-acetylglucosaminyltransferase Activity Regulation Of Cell Junction Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cellular Response To Norepinephrine Stimulus Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Negative Regulation Of Cell Communication Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Killing Of Cells Of Another Organism Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding	Arginine Metabolic Process Nitric Oxide Biosynthetic Process Alpha-amino Acid Metabolic Process Regulation Of Neurotransmitter Uptake Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Amino Acid Metabolic Process Adherens Junction Organization Glutamine Family Amino Acid Metabolic Process Striated Muscle Contraction Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Caveola L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process L-glutamate Gamma-semialdehyde Dehydrogenase Activity Cell Periphery Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Sarcolemma Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Amino Acid Catabolic Process Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity L-proline Catabolic Process To L-glutamate Positive Regulation Of Synaptic Transmission, Dopaminergic Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuropilin Signaling Pathway Regulation Of Serotonin Uptake L-amino Acid Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process L-proline Catabolic Process Cell-cell Junction Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction
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