ARG1

Description		arginase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Azurophil Granule Lumen Specific Granule Lumen
	Molecular Function	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding
	Biological Process	Urea Cycle Adaptive Immune Response Immune System Process Arginine Metabolic Process L-arginine Catabolic Process Response To Nematode Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Neutrophil degranulation Urea cycle
Drugs		Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases		Hyperargininemia
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Serum metabolite levels ( 33031748) Type 2 diabetes ( 30054458)
Novel Interacting Genes		6 novel interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Interacting Genes		6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Entrez ID		383
HPRD ID		01947
Ensembl ID		ENSG00000118520
Uniprot IDs		A0A5F9ZH78 P05089
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F 7K4G 7K4H 7K4I 7K4J 7K4K 7KLK 7KLL 7KLM 7LEX 7LEY 7LEZ 7LF0 7LF1 7LF2 8AUP 8E5M 8E5N
Enriched GO Terms of Interacting Partners?		Arginine Metabolic Process Nitric Oxide Biosynthetic Process Alpha-amino Acid Metabolic Process Regulation Of Neurotransmitter Uptake Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Amino Acid Metabolic Process Adherens Junction Organization Glutamine Family Amino Acid Metabolic Process Striated Muscle Contraction Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Caveola L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process L-glutamate Gamma-semialdehyde Dehydrogenase Activity Cell Periphery Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Sarcolemma Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Amino Acid Catabolic Process Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity L-proline Catabolic Process To L-glutamate Positive Regulation Of Synaptic Transmission, Dopaminergic Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuropilin Signaling Pathway Regulation Of Serotonin Uptake L-amino Acid Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process L-proline Catabolic Process Cell-cell Junction Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction
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